Desmopressin Acetate ho Phekola Bohareng ba Diabetes Insipidus
Lintlha tsa Sehlahisoa
| Lebitso | "Desmopressin" |
| Nomoro ea CAS | 16679-58-6 |
| Mokhoa oa limolek'hule | Setšoantšo sa C46H64N14O12S2 |
| Boima ba molek'hule | 1069.22 |
| Nomoro ea EINECS | 240-726-7 |
| Ho potoloha ho itseng | D25 +85.5 ± 2° (e baloang bakeng sa peptide ea mahala) |
| Botenya | 1.56±0.1 g/cm3(E boletsoeng esale pele) |
| Nomoro ea RTECS. | YW9000000 |
| Maemo a polokelo | Boloka ho 0°C |
| Solubility | H2O: soluble20mg/mL, e hlakileng, ha e na mebala |
| Acidity coefficient | (pKa) 9.90±0.15 (E boletsoeng esale pele) |
Litlhaloso tse tšoanang
MPR-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2;MINIRIN;[DEAMINO1, DARG8] VASOPRESSIN;[DEAMINO-CYS1, D-ARG8]-VASOPRESSIN;DDAVP, MOTHO;DESMOPRESSIN;DESMOPRESSIN, BATHO;DESAMINO-[D-ARG8] VASOPRESSIN
Lipontšo
(1) Phekolo ea lefu la tsoekere le bohareng la insipidus.Ka mor'a hore moriana o fokotse ho tsoa ha moroto, o fokotsa maqhubu a moroto le ho fokotsa nocturia.
(2) Kalafo ea enuresis ea bosiu (bakuli ba lilemo li 5 kapa ho feta).
(3) Lekola ts'ebetso ea khatello ea moroto oa renal, 'me u etse tlhahlobo e fapaneng ea ts'ebetso ea renal.
(4) Bakeng sa haemophilia le mafu a mang a mali, sehlahisoa sena se ka khutsufatsa nako ea ho tsoa ha mali le ho thibela mali.E ka fokotsa palo ea tahlehelo ea mali ka mor'a opereishene le ho tsoa ka mor'a ts'ebetso;haholo-holo hammoho le khatello ea mali e laoloang ka mokhoa o utloahalang nakong ea opereishene, e ka fokotsa mali a tsoang ka har'a ts'ebetso ho tsoa mekhoeng e fapaneng, 'me ea fokotsa ho tsoa ka mor'a ts'ebetso, e leng se ka phethang karolo e molemo ho sireletsa mali.
Phekolo ea lefu la tsoekere insipidus
Lefu la tsoekere insipidus ke bothata ba metabolism ea metsi bo khetholloang ke ho tsoa moroto, polydipsia, hypoosmolarity le hypernatremia.Khaello e itseng kapa e felletseng ea vasopressin (bolwetse bo bohareng ba lefu la tsoekere insipidus), kapa ho haella ha renal ea vasopressin (nephrogenic diabetes insipidus) e ka qala.Ka kakaretso, lefu la tsoekere insipidus le tšoana le polydipsia ea mantlha, boemo boo ho bona ho noa metsi a mangata ho bakoang ke ho se sebetse hantle ha mokhoa oa taolo kapa lenyora le sa tloaelehang.Ho fapana le polydipsia ea mantlha, keketseho ea ho noa metsi ho bakuli ba nang le lefu la tsoekere insipidus ke karabelo e ts'oanang le liphetoho khatellong ea osmotic kapa bophahamo ba mali.
