Leuprorelin Acetate Regulates Secretion of Gonadal Hormones Featured Image

Leuprorelin Acetate e Laola Sephiri sa Li-Hormone tsa Gonadal

Tlhaloso e Khutšoanyane:

Lebitso: Leuprorelin

Nomoro ea CAS: 53714-56-0

Mokhoa oa molek'hule: C59H84N16O12

Boima ba molek'hule: 1209.4

Nomoro ea EINECS: 633-395-9

Potoloho e khethehileng: D25 -31.7° (c = 1 ho 1% acetic acid)

Boima: 1.44±0.1 g/cm3(E boletsoeng esale pele)

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Lintlha tsa Sehlahisoa

Lebitso	Leuprorelin
Nomoro ea CAS	53714-56-0
Mokhoa oa limolek'hule	C59H84N16O12
Boima ba molek'hule	1209.4
Nomoro ea EINECS	633-395-9
Ho potoloha ho itseng	D25 -31.7° (c = 1 ho 1% acetic acid)
Botenya	1.44±0.1 g/cm3(E boletsoeng esale pele)
Boemo ba polokelo	-15°C
Sebopeho	E makhethe
Acidity coefficient	(pKa) 9.82±0.15 (E boletsoeng esale pele)
Ho qhibiliha ha metsi	E qhibiliha ka metsing ka 1mg/ml

Litlhaloso tse tšoanang

LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEMONE-LUTEMONE DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(HUMAN)

Phello ea Pharmacological

Leuprolide, goserelin, triprelin, le nafarelin ke litlhare tse 'maloa tse sebelisoang hangata litloaelong tsa bongaka ho tlosa mae a bomme bakeng sa ho alafa mofetše oa matsoele pele ho menopausal le mofetše oa senya.(e bitsoang lithethefatsi tsa GnRH-a), lithethefatsi tsa GnRH-a li tšoana ka sebopeho le GnRH 'me li hlōlisana le li-receptor tsa pituitary GnRH.Ke hore, gonadotropin e hlahisoang ke pituitary e fokotseha, e lebisang ho fokotseha ho hoholo ha hormone ea thobalano e hlahisoang ke ovary.

Leuprolide ke analoge ea gonadotropin-release hormone (GnRH), peptide e entsoeng ka li-amino acid tse 9.Sehlahisoa sena se ka thibela ka katleho mosebetsi oa tsamaiso ea pituitary-gonadal, ho hanyetsa li-enzyme tsa proteolytic le kamano ea pituitary receptor ea GnRH e matla ho feta GnRH, 'me mosebetsi oa ho khothalletsa ho lokolloa ha hormone ea luteinizing (LH) ke hoo e ka bang ka makhetlo a 20. ea GnRH.E boetse e na le phello e matla ea inhibitory mosebetsing oa pituitary-gonad ho feta GnRH.Boemong ba pele ba kalafo, follicle stimulating hormone (FSH), LH, estrogen kapa androgen e ka eketseha ka nakoana, ebe, ka lebaka la ho fokotseha ha karabelo ea tšoelesa ea pituitary, secretion ea FSH, LH le estrogen kapa androgen ea thibeloa. ho fella ka ho itšetleha ka li-hormone tsa thobalano.Mafu a thobalano (a kang kankere ea prostate, endometriosis, joalo-joalo) a na le phello ea phekolo.

Hajoale, letsoai la acetate la leuprolide le sebelisoa haholo ka bongaka, hobane ts'ebetso ea leuprolide acetate e tsitsitse haholoanyane mocheso oa kamore.Mokelikeli o lokela ho lahloa.E ka sebelisoa bakeng sa kalafo castration ea lithethefatsi endometriosis le uterine fibroids, bohareng precocious puberty, premenopausal kankere ea matsoele le kankere ea tšoelesa ea senya, 'me hape bakeng sa tshebetso uterine tsoa mali e contraindicated kapa e sa sebetseng bakeng sa phekolo e tloaelehileng ea hormone.E ka boela ea sebelisoa e le premedication pele endometrial resection, e ka evenly tšesaane endometrium, fokotsa edema, le fokotsa bothata ba ho buuoa.

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