Carbetocin ho Thibela ho Honyela ha Uterine le ho tsoa mali ka mor'a ho pepa
Lintlha tsa Sehlahisoa
| Lebitso | CARBETOCIN |
| Nomoro ea CAS | 37025-55-1 |
| Mokhoa oa limolek'hule | Setšoantšo sa C45H69N11O12S |
| Boima ba molek'hule | 988.17 |
| Nomoro ea EINECS | 253-312-6 |
| Ho potoloha ho itseng | D -69.0° (c = 0.25 ho 1M acetic acid) |
| Ntho e belang | 1477.9±65.0 °C (E boletsoeng esale pele) |
| Botenya | 1.218±0.06 g/cm3(E boletsoeng esale pele) |
| Maemo a polokelo | -15°C |
| Sebopeho | phofo |
Litlhaloso tse tšoanang
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBEETWEENBUTYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2) -1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2) -OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Mosebetsi oa likokoana-hloko
Carbetocin, analog ea oxytocin (OT), ke agonist ea oxytocin receptor e nang le Ki ea 7.1 nM. Carbetocin e na le kamano e phahameng (Ki = 1.17 μM) bakeng sa chimeric N-terminus ea oxytocin receptor. Carbetocin e na le monyetla oa ho etsa lipatlisiso tsa ho tsoa mali ka mor'a ho pepa. Carbetocin e ka phunyeletsa mokoallo oa mali le boko 'me e na le ts'ebetso e kang ea antidepressant ka ho kenya li-receptor tsa oxytocin ho CNS.
Mosebetsi
Carbetocin ke analoge ea maiketsetso ea nako e telele ea oxytocin 8-peptide e nang le litšobotsi tsa agonist, 'me thepa ea eona ea bongaka le ea meriana e tšoana le ea oxytocin ea tlhaho. Joalo ka oxytocin, carbetocin e tlama ho li-receptor tsa lihomone tsa mesifa e boreleli ea uterine, e bakang ho honyela ho hoholo ha popelo, ho eketsa makhetlo a eona le ho eketsa molumo oa popelo motheong oa likhohlano tsa pele. Maemo a li-receptor tsa Oxytocin ka popelong a tlase maemong ao e seng moimana, a eketseha nakong ea bokhachane, 'me a phahama nakong ea ho pepa. Ka hona, carbetocin ha e na phello ho lesea le se nang moimana, empa e na le phello e matla ea "contractile" ea uterine ka popelong ea moimana le popelong e sa tsoa hlahisoa.
Fetola Litaolo
Liphetoho li laoloa ho latela mokhoa. Ho ipapisitsoe le tšusumetso le kotsi le ho teba, liphetoho li aroloa e le tse kholo, tse nyane le tsa Sebaka. Liphetoho tsa sebaka sa marang-rang li na le tšusumetso e fokolang ho polokeho le boleng ba sehlahisoa, ka hona ha li hloke tumello le tsebiso ho moreki; Liphetoho tse nyane li na le phello e itekanetseng polokehong le boleng ba sehlahisoa, 'me li hloka ho tsebisa moreki; Liphetoho tse kholo li na le tšusumetso e phahameng ho polokeho le boleng ba sehlahisoa, 'me li hloka tumello ke moreki.
Ho latela ts'ebetso, taolo ea phetoho e qala ka ts'ebeliso ea phetoho eo ho eona lintlha tsa phetoho le tse utloahalang bakeng sa phetoho li hlalosoang. Tlhahlobo e etsoa ka mor'a kopo, e etsoang ke mafapha a amehang a taolo ea phetoho. Ho sa le joalo, taolo ea phetoho e arotsoe ka boemo bo boholo, boemo ba kakaretso le boemo bo nyane. Ka mor'a tlhahlobo e nepahetseng hammoho le lihlopha, taolo eohle ea phetoho ea boemo e lokela ho amoheloa ke QA Manager. Taolo ea phetoho e etsoa ka mor'a tumello ho latela moralo oa ts'ebetso. Taolo ea phetoho e qetella e koetsoe ka mor'a hore QA e tiise hore taolo ea phetoho e sebelisitsoe ka nepo. Haeba ho kenyelletsa tsebiso ea moreki, moreki o lokela ho tsebisoa ka nako kamora hore taolo ea phetoho e amoheloe
