Linaclotide for Gastrointestinal Disorders 851199-59-2 Featured Image

Linaclotide bakeng sa Mathata a Gastrointestinal 851199-59-2

Tlhaloso e Khutšoanyane:

Lebitso: Linaclotide

Nomoro ea CAS: 851199-59-2

Mokhoa oa molek'hule: C59H79N15O21S6

Boima ba molek'hule: 1526.74

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Lintlha tsa Sehlahisoa

Lebitso	Linaclotide
Nomoro ea CAS	851199-59-2
Mokhoa oa limolek'hule	C59H79N15O21S6
Boima ba molek'hule	1526.74

Litlhaloso tse tšoanang

Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteineyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteineyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)

Tlhaloso

Linaclotide, sebopeho sa peptide ea maiketsetso e nang le li-amino acid tse 14, e amana le lelapa la endogenous guanosine peptide mme ke eona feela lithethefatsi tse amohetsoeng ke GC-C (guanylate) Cyclase-C) tse amohetsoeng ke FDA bakeng sa ho alafa lefu la mala le pipitlelano (IBS- C) le lefu le sa foleng la idiopathic constipation (CIC) ho batho ba baholo.

Lintho tsa Lik'hemik'hale

Linaclotide ke phofo ea amorphous e tšoeu ho isa ho e tšoeu;qhibilihang hanyenyane ka metsing le tharollo ea sodium chloride e nang le metsi (0.9%).

Kamoo e sebetsang kateng

Linaclotide ke guanylate cyclase-C receptor agonist (GCCA) e nang le ts'ebetso ea visceral analgesic le endocrine.Ka bobeli linaclotide le metabolite ea eona e sebetsang li ka hokahana le guanylate cyclase-C (GC-C) receptor sebakeng se khanyang sa epithelium ea mala a manyane.Mehlala ea liphoofolo, linaclotide e fokotsa bohloko ba visceral mme e eketsa phetisetso ea mala ka ho kenya tšebetsong GC-C, 'me ho batho, moriana o boetse o eketsa lipalangoang.Sephetho sa ts'ebetso ea GC-C ke keketseho ea intracellular le extracellular cGMP (cyclic guanosine monophosphate) concentrations.Extracellular cGMP e ka fokotsa ts'ebetso ea methapo ea kutlo e bohloko le ho fokotsa bohloko ba visceral ho liphoofolo tsa mohlala.Intracellular cGMP e ka eketsa secretion ea chloride le bicarbonate ka maleng a manyenyane ka ho kenya tšebetsong CFTR (cystic fibrosis transmembrane conductance regulator), e qetellang e lebisa ho eketseha ha mokelikeli o monyenyane oa mala le lebelo la ho tsamaea ha mala a manyenyane.

LBH

A na u fana ka tiisetso ea ho tlisa lihlahisoa tse sireletsehileng?

Ee, re lula re sebelisa liphutheloana tsa boleng bo holimo tsa kantle ho naha.Re boetse re sebelisa liphutheloana tse khethehileng tsa kotsi bakeng sa thepa e kotsi le barekisi ba netefalitsoeng ba polokelo e batang bakeng sa lintho tse sa utloeng bohloko.Litlhokahalo tsa ho paka ka litsebi le tse sa tloahelehang tsa ho paka li ka ba le tefiso e eketsehileng.

Ho thoe'ng ka litefiso tsa thomello?

Litšenyehelo tsa ho romela thepa li itšetlehile ka tsela eo u khethang ho fumana thepa ka eona.Express hangata ke tsela e potlakileng empa hape e turu haholo.Ka thepa ea leoatleng ke tharollo e molemohali bakeng sa chelete e ngata.Hantle-ntle litefiso tsa thepa re ka u fa tsona ha feela re tseba lintlha tse qaqileng tsa palo, boima le tsela.Ka kopo ikopanye le rona bakeng sa lintlha tse ling.

E fetileng: Ganirelix Acetate Peptide API

E 'ngoe: Semaglutide bakeng sa Mofuta oa 2 oa lefu la tsoekere

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