CAS | 204656-20-2 | Foromo ea limolek'hule | C172H265N43O51 |
Boima ba Molek'hule | 3751.20 | Ponahalo | Bosoeu |
Boemo ba polokelo | Ho hanyetsa khanya, likhato tse 2-8 | Sephutheloana | Aluminium foil mokotla / vial |
Bohloeki | ≥98% | Lipalangoang | Cold Chain le phano e pholileng ea polokelo |
Sejo se sebetsang:
Liraglutide (analogue ea glucagon-like peptide-1 (GLP-1) e hlahisoang ke tomoso ka theknoloji ea ho kopanya liphatsa tsa lefutso).
Lebitso la lik'hemik'hale:
Arg34Ls26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
Lisebelisoa tse ling:
Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid le/kapa Sodium Hydroxide (e le pH Adjusters Feela), Phenol, le Metsi a Ente.
Mofuta oa 2 oa lefu la tsoekere
Liraglutide e ntlafatsa taolo ea tsoekere ea mali.E fokotsa hyperglycemia e amanang le lijo (lihora tse 24 kamora ho tsamaisoa) ka ho eketsa tlhahiso ea insulin (feela) ha ho hlokahala ka ho eketsa maemo a tsoekere, ho lieha ho tsoa ka mpeng, le ho hatella secretion ea prandial glucagon.
E loketse bakuli bao tsoekere ea bona ea mali e ntseng e sa laolehe hantle ka mor'a tekanyetso e phahameng e mamelloang ea metformin kapa sulfonylureas feela.E sebelisoa hammoho le metformin kapa sulfonylureas.
E sebetsa ka mokhoa o itšetlehileng ka tsoekere, ho bolelang hore e tla susumetsa tlhahiso ea insulin ha feela maemo a tsoekere ea mali a phahame ho feta a tloaelehileng, ho thibela "ho feta".Ka lebaka leo, e bonts'a kotsi e fokolang ea hypoglycemia.
E na le monyetla oa ho thibela apoptosis le ho susumetsa nchafatso ea lisele tsa beta (tse bonoang lithutong tsa liphoofolo).
E fokotsa takatso ea lijo le ho thibela boima ba 'mele, joalo ka ha ho bonts'itsoe thutong ea hlooho-ho-hlooho khahlano le glimepiride.
Ketso ea Pharmacological
Liraglutide ke analog ea GLP-1 e nang le 97% ea tatellano ea homology ho GLP-1 ea motho, e ka kopanyang le ho kenya tšebetsong receptor ea GLP-1.GLP-1 receptor ke sepheo sa matsoalloa a GLP-1, endogenous incretin hormone e khothalletsang secretion ea glucose e itšetlehileng ka insulin ho tsoa liseleng tsa pancreatic β.Ho fapana le GLP-1 ea matsoalloa, lintlha tsa pharmacokinetic le pharmacodynamic tsa liraglutide ho batho li loketse mokhoa oa ho noa hanngoe ka letsatsi.Ka mor'a ente ea subcutaneous, mokhoa oa eona oa ketso ea nako e telele o kenyelletsa: ho ikamahanya le ho iphelisa ho liehisa ho monya;tlamahano ho albumin;Botsitso bo phahameng ba enzyme mme ka hona halofo ea bophelo bo bolelele ba plasma.
Ts'ebetso ea liraglutide e hokahane le tšebelisano e ikhethileng le receptor ea GLP-1, e bakang keketseho ea cyclic adenosine monophosphate (cAMP).Liraglutide e susumetsa secretion ea insulin ka mokhoa o itšetlehileng ka tsoekere, ha e ntse e fokotsa secretion ea glucagon ka mokhoa o itšetlehileng ka tsoekere.
Ka hona, ha tsoekere ea mali e phahama, tlhahiso ea insulin ea hlohlelletsoa, ha secretion ea glucagon e thibetsoe.Ka lehlakoreng le leng, liraglutide e fokotsa secretion ea insulin nakong ea hypoglycemia ntle le ho ama secretion ea glucagon.Mochine oa hypoglycemic oa liraglutide o boetse o kenyelletsa ho lelefatsa ho fokolang ha nako ea ho tsoa ka mpeng.Liraglutide e fokotsa boima ba 'mele le mafura a' mele ka ho fokotsa tlala le matla.