Lihlahisoa
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High Purity Peptides Retatrutide 10mg bakeng sa ho lahleheloa ke boima ba 'mele le lefu la tsoekere
Bohloeki: >99%
Naha: Powder ea Lyophilized
Ponahalo: Phofo e tšoeu
Tlhaloso: 5mg/10mg/15mg/20mg/30mg
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Retatrutide
Retaglutide ke sethethefatsi se secha sa dipeptidyl peptidase-4 (DPP-4) inhibitor class hypoglycemic se ka thibelang ho senyeha ha glucagon-like peptide-1 (GLP-1) le glucose e itšetlehileng ka insulin-releasing polypeptide (GIP) ka enzyme ea DPP-4 ka maleng le maling, ka ho lelefatsa ts'ebetso ea bona ea insulin, ho lelefatsa ts'ebetso ea bona ea "insulin". basal level ea insulin e itima lijo, ha e ntse e fokotsa tlhahiso ea glucagon ka lisele tsa pancreatic α, ka tsela eo e laola ka katleho tsoekere ea mali ea postprandial. E sebetsa hantle ho latela phello ea hypoglycemic, mamello le ho latela melao.
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E kenyelletsa sodium
Inclisiran sodium API (Active Pharmaceutical Ingredient) e ithutoa haholo-holo tšimong ea ho kena-kenana le RNA (RNAi) le therapeutics ea pelo. Joalo ka siRNA e nang le likarolo tse peli e shebileng mofuta oa PCSK9, e sebelisoa lipatlisisong tsa pele le tsa bongaka ho lekola maano a nako e telele a ho khutsisa liphatsa tsa lefutso bakeng sa ho theola LDL-C (low-density lipoprotein cholesterol). E boetse e sebetsa e le motsoako oa mohlala bakeng sa ho batlisisa mekhoa ea phepelo ea siRNA, botsitso, le phekolo ea RNA e lebisitsoeng sebeteng.
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Fmoc-Gly-Gly-OH
Fmoc-Gly-Gly-OH ke dipeptide e sebelisoang e le motheo oa moaho ho solid-phase peptide synthesis (SPPS). E na le masala a mabeli a glycine le N-terminus e sirelelitsoeng ke Fmoc, e lumellang ho lelefatsa ketane ea peptide e laoloang. Ka lebaka la boholo bo nyane ba glycine le ho feto-fetoha ha maemo, dipeptide ena hangata e ithutoa maemong a matla a mokokotlo oa peptide, moralo oa lihokela, le sebopeho sa sebopeho ho li-peptide le liprotheine.
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Fmoc-Thr(tBu)-Phe-OH
Fmoc-Thr(tBu)-Phe-OH ke sebaka sa kaho sa dipeptide se atisang ho sebelisoa ho solid-phase peptide synthesis (SPPS). Sehlopha sa Fmoc (9-fluorenylmethyloxycarbonyl) se sireletsa N-terminus, ha sehlopha sa tBu (tert-butyl) se sireletsa ketane ea lehlakore ea hydroxyl ea threonine. Peptide ena e sirelelitsoeng e ithutoa ka karolo ea eona ea ho nolofatsa katoloso e nepahetseng ea peptide, ho fokotsa lebelo la morabe, le ho etsa mohlala oa tatellano e ikhethileng ea sebopeho sa protheine le lithuto tsa tšebelisano.
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AEEA-AEEA
AEEA-AEEA ke hydrophilic, sepakapaka se tenyetsehang se sebelisoang hangata ho lipatlisiso tsa peptide le lithethefatsi. E na le li-unit tse peli tse thehiloeng ho ethylene glycol, e leng se etsang hore e be molemo bakeng sa ho ithuta liphello tsa bolelele ba li-linker le ho feto-fetoha ha litšebelisano tsa limolek'hule, ho qhibiliha, le ts'ebetso ea likokoana-hloko. Hangata bafuputsi ba sebelisa likarolo tsa AEEA ho lekola hore na li-spacers li susumetsa ts'ebetso ea li-antibody-drug conjugates (ADCs), li-conjugate tsa lithethefatsi tsa peptide, le li-bioconjugate tse ling.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Motsoako ona ke motsoako o sirelelitsoeng, o sebetsang oa lysine o sebelisoang ho peptide synthesis le nts'etsopele ea conjugate ea lithethefatsi. E na le sehlopha sa Fmoc bakeng sa tšireletso ea N-terminal, le phetoho ea ketane ea mahlakoreng ka Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), le AEEA (aminoethoxyethoxyacetate). Likarolo tsena li etselitsoe ho ithuta litlamorao tsa lipidation, chemistry ea spacer, le tokollo ea lithethefatsi e laoloang. E batlisisoa haholo molemong oa maano a lihlahisoa, lihokelo tsa ADC, le li-peptide tse sebetsanang le membrane.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Motsoako ona ke motsoako oa lysine o fetotsoeng o sebelisoang ho peptide synthesis, haholo-holo bakeng sa ho aha li-conjugate tsa peptide tse lebisitsoeng kapa tse sebetsang ka bongata. Sehlopha sa Fmoc se lumella ho qaptjoa ha mohato ka mohato ka Fmoc solid-phase peptide synthesis (SPPS). Ketane ea mahlakoreng e fetotsoe ka motsoako oa stearic acid (Ste), γ-glutamic acid (γ-Glu), le lihokelo tse peli tsa AEEA (aminoethoxyethoxyacetate), tse fanang ka hydrophobicity, thepa ea tefiso, le sebaka se feto-fetohang. Hangata e ithutoa ka karolo ea eona litsamaisong tsa phano ea lithethefatsi, ho kenyeletsoa li-antibody-drug conjugates (ADCs) le li-peptide tse kenang liseleng.
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Liraglutide Anti-Diabetics bakeng sa Taolo ea Tsoekere ea Mali CAS NO.204656-20-2
Sejo se sebetsang:Liraglutide (analogue ea glucagon-like peptide-1 (GLP-1) e hlahisoang ke tomoso ka theknoloji ea ho kopanya liphatsa tsa lefutso).
Lebitso la lik'hemik'hale:Arg34Ls26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
Lisebelisoa tse ling:Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid le/kapa Sodium Hydroxide (e le pH Adjusters Feela), Phenol, le Metsi a Ente.
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Leuprorelin Acetate e Laola Sephiri sa Li-Hormone tsa Gonadal
Lebitso: Leuprorelin
Nomoro ea CAS: 53714-56-0
Mokhoa oa molek'hule: C59H84N16O12
Boima ba molek'hule: 1209.4
Nomoro ea EINECS: 633-395-9
Potoloho e khethehileng: D25 -31.7° (c = 1 ho 1% acetic acid)
Boima: 1.44±0.1 g/cm3(E boletsoeng esale pele)
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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHke tetrapeptide e sirelelitsoeng e sebelisoang ho peptide synthesis le lithuto tsa sebopeho. Sehlopha sa Boc (tert-butyloxycarbonyl) se sireletsa N-terminus, ha lihlopha tsa Trt (trityl) li sireletsa liketane tse ka thōko tsa histidine le glutamine ho thibela liketso tse sa batleheng. Ho ba teng ha Aib (α-aminoisobutyric acid) ho khothalletsa ho lumellana ha helical le ho matlafatsa botsitso ba peptide. Peptide ena e bohlokoa bakeng sa ho etsa lipatlisiso tsa ho mena ha peptide, botsitso, le joalo ka sekhafo sa ho rala li-peptide tse sebetsang ka bioloji.
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BPC-157
BPC-157 API e sebelisa mokhoa o tiileng oa ho kopanya likarolo (SPPS):
Bohloeki bo phahameng: ≥99% (ho lemoha HPLC)
Masala a litšila a tlase, ha a na endotoxin, ha a na tšilafalo ea tšepe e boima
Ho tsitsa ha sehlopha, ho pheta-pheta ho matla, ts'ebeliso ea boemo ba ente ea tšehetso
Ts'ehetso ea phepelo ea boemo ba gram le kilogram ho fihlela litlhoko tsa mekhahlelo e fapaneng ho tloha ho R&D ho isa indastering.