Hexarelin

Tlhaloso e Khutšoanyane:

Hexarelin ke synthetic hormone secretagogue peptide (GHS) le agonist e matla ea GHSR-1a, e ntlafalitsoeng ho susumetsa ho lokolloa ha hormone e sa feleng (GH). Ke ea lelapa la ghrelin mimetic mme e entsoe ka li-amino acid tse tšeletseng (hexapeptide), e fanang ka botsitso bo ntlafetseng ba metabolism le liphello tse matla tsa ho lokolla GH ha li bapisoa le li-analogue tsa pejana tse kang GHRP-6.

Likarolo tsa API :

Bohloeki ≥ 99%

E hlahisoa ka solid-phase peptide synthesis (SPPS)

Litekanyetso tse kang GMP, endotoxin e tlase le masala a solvent

Phepelo e feto-fetohang: R&D ho isa tekanyong ea khoebo

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Hexarelin API - Tlhaloso ea lihlahisoa

Hexarelinke ntho ea maiketsetsoHormone ea ho hōla secretagogue peptide (GHS)le matlaGHSR-1a agonist, e etselitsoeng ho susumetsaho lokolloa ha hormone ea kholo ea endogenous (GH).. Ke ealelapa la ghrelin mimetic'me e entsoe ka li-amino acid tse tšeletseng (hexapeptide), e fanang ka botsitso bo ntlafetseng ba metabolism le liphello tse matla tsa ho lokolla GH ha li bapisoa le li-analogue tsa pejana tse kang GHRP-6.

Hexarelin e ithutoa haholo bakeng sa lits'ebetso tsa eona hoendocrinology, ho senyeha ha mesifa, ho lokisa pelo, le litlhare tse thibelang botsofali, ka lebaka la bokhoni ba eona ba ho phahamisa GH leInsulin-like growth factor 1 (IGF-1)maemo ntle le ho hlahisa lihomone tsa kantle ka kotloloho.

Mokhoa oa Ts'ebetso

Hexarelin e tlamella hoHormone ea ho hola secretagogue receptor (GHSR-1a)ka pituitary le hypothalamus, ho etsisa ketso eaghrelin- tlala ea tlhaho ea 'mele le hormone e lokollang GH.

Liketso tsa bohlokoa tsa fisioloji:

E susumetsa ho lokolloa ha pulsatile GH
E eketsa ho potolohaIGF-1maemo
Phatlalatsoliphello tsa anabolic(khōlo ea mesifa, ho hlaphoheloa)
Tšehetsametabolism ea mafuralenchafatso ea lisele
E ka bonts'alefu la peloleanti-apoptoticliphello

Ho fapana le li-peptide tse ling tsa GHS, Hexarelin e etsa joaloha e eketse cortisol kapa prolactin haholo, e fanang ka boemo bo hloekileng ba endocrine.

Lipatlisiso le Matla a Phekolo

1. Khōlo ea mesifa le ho hlaphoheloa

Phatlalatsoboima ba mmele o mosesanentshetsopele
E matlafatsaho lokisa le ho nchafatsa mesifa
Ke ithutile hosarcopenia, cachexia, le ho hlaphoheloa ka mor'a ho buuoa

2. Tšireletso ea pelo

Liphuputso tsa preclinical li bontšamosebetsi o ntlafetseng oa peloka mor'a kotsi ea myocardial
E fokotsafibrosis ea pelole ho ntlafatsakarolo e ka ho le letšehali ea ejection ea ventricular
Tšebeliso e ka bang tengho hloleha ha pelolebotsofali ba pelomehlala