Ganirelix Acetate Peptide API

Tlhaloso e Khutšoanyane:

Lebitso: Ganirelix Acetate

Nomoro ea CAS: 123246-29-7

Mokhoa oa molek'hule: C80H113ClN18O13

Boima ba molek'hule: 1570.34

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Lebitso	Ganirelix Acetate
Nomoro ea CAS	123246-29-7
Mokhoa oa limolek'hule	Setšoantšo sa C80H113ClN18O13
Boima ba molek'hule	1570.34

Litlhaloso tse tšoanang

Ac-DNal-DCpa-DPal-Ser-Tyr-DHr(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate;GANIRELIX;Ganirelix Acetate USP/EP/

Tlhaloso

Ganirelix ke motsoako oa maiketsetso oa decapeptide, 'me letsoai la eona la acetate, Ganirelix acetate ke mohanyetsi oa gonadotropin-releasing hormone (GnRH) receptor antagonist.Tatelano ea amino acid ke: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro- D- Ala-NH2.Haholo-holo litabeng tsa bongaka, e sebelisoa ho basali ba nang le thuso ea theknoloji ea ho ba le bana e laoloang ke mananeo a ts'usumetso ea mahe a bomme ho thibela litlhōrō tsa li-hormone tsa luteinizing pele ho nako le ho phekola mathata a ho ba le bana ka lebaka lena.Lithethefatsi li na le litšobotsi tse fokolang tse mpe, tekanyo e phahameng ea bokhachane le nako e khutšoanyane ea phekolo, 'me e na le melemo e totobetseng ha e bapisoa le meriana e tšoanang le ea bongaka.

Ketso ea Pharmacological

Ho lokolloa ha pulsatile ea gonadotropin-releasing hormone (GnRH) ho susumetsa motsoako le tlhahiso ea LH le FSH.Khafetsa ea LH pulses ka mekhahlelo e bohareng le ea morao ea follicular ke hoo e ka bang 1 ka hora.Li-pulse tsena li bonahala ka ho phahama ha nakoana ho serum LH.Nakong ea bohareng ba ho ilela khoeli, ho lokolloa ho hoholo ha GnRH ho baka ho eketseha ha LH.Ho buuoa ha LH bohareng ba ho ilela khoeli ho ka etsa hore ho be le likarabo tse 'maloa tsa 'mele, ho akarelletsa le: ovulation, oocyte meiotic resumption, le corpus luteum formation.Ho thehoa ha corpus luteum ho etsa hore maemo a progesterone a serum a phahame, ha maemo a estradiol a theoha.Ganirelix acetate ke mohanyetsi oa GnRH ea thibelang li-receptor tsa GnRH ka li-pituitary gonadotrophs le litsela tse latelang tsa phetisetso.E hlahisa thibelo e potlakileng, e ka fetoloang ea secretion ea gonadotropin.Tšusumetso e thibelang ea ganirelix acetate ho secretion ea LH ea pituitary e ne e le matla ho feta ea FSH.Ganirelix acetate e ile ea hloleha ho fana ka tokollo ea pele ea li-gonadotropin tsa endogenous, tse tsamaellanang le bohanyetsi.Ho hlaphoheloa ka ho feletseng ha maemo a LH le FSH a pituitary ho etsahetse nakong ea lihora tse 48 ka mor'a hore ganirelix acetate e khaotsoe.

E fetileng: Cetrorelix Acetate ho Thibela Ovulation Pele ho Nako 120287-85-6

E 'ngoe: Linaclotide bakeng sa Mathata a Gastrointestinal 851199-59-2

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