Daptomycin 103060-53-3 bakeng sa mafu a tšoaetsanoang
Lintlha tsa Sehlahisoa
| Lebitso | Daptomycin |
| Nomoro ea CAS | 103060-53-3 |
| Mokhoa oa limolek'hule | C72H101N17O26 |
| Boima ba molek'hule | 1620.67 |
| Nomoro ea EINECS | 600-389-2 |
| Sebaka se qhibilihang | 202-204°C |
| Ntho e belang | 2078.2±65.0 °C (E boletsoeng esale pele) |
| Botenya | 1.45±0.1 g/cm3(E boletsoeng esale pele) |
| flash point | 87℃ |
| Maemo a polokelo | E koaletsoe ka sehatsetsing, ka tlas'a -20°C |
| Solubility | Methanol: e qhibilihang ka 5mg/mL |
| Acidity coefficient | (pKa) 4.00±0.10 (E boletsoeng esale pele) |
| Sebopeho | phofo |
| Mmala | e se nang mmala ho isa bosehla bo fokolang |
Litlhaloso tse tšoanang
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R) -3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Tlhaloso
Sethibela-mafu daptomycin ke lithibela-mafu tsa cyclic lipopeptide tse nang le sebopeho se secha se ntšitsoeng moro oa belisoa oa Streptomyces (S. reseosporus), e sitisang biosynthesis ea baktheria cell wall peptidoglycan ka ho sitisa ho tsamaisoa ha li-amino acid ka lera la sele.Ho fetola thepa ea lera la cytoplasmic ho ka sitisa lera la baktheria ka litsela tse ngata 'me ka potlako ho bolaea libaktheria tsa Gram-positive.Ntle le bokhoni ba eona ba ho sebetsana le libaktheria tse amanang le Gram-positive, daptomycin e bohlokoa haholo bakeng sa mefuta e ka thoko e bontšitseng ho hanyetsa methicillin, vancomycin, le linezolid in vitro.E na le ts'ebetso e matla, 'me thepa ena e na le litlamorao tsa bohlokoa tsa kliniki ho bakuli ba tšoaelitsoeng haholo.Eosinophilic pneumonia ke lefu le sa tloaelehang le le kotsi haholo le nang le matšoao a kenyelletsang feberu, ho khohlela, ho hema ka thata, le ho hema ka thata.
Phello ea Antibacterial
Daptomycin e na le ts'ebetso e ntle ea bacteriostatic khahlano le libaktheria tse fapaneng tse hananang le lithibela-mafu, joalo ka MIC=0.06-0.5 μg/ml bakeng sa Staphylococcus aureus (MRSA) e hanyetsanang le methicillin, le Staphylococcus aureus (MRSA) e hanyetsanang le methicillin.MIC=0.0625～1μg/ml bakeng sa baktheria, MIC=0.12～0.5μg/ml bakeng sa Staphylococcus epidermidis e hanyetsanang le oxacillin, MIC=2.5μg/ml bakeng sa enterococcus e hanyetsanang haholo le lithibela-mafu tsa aminoglycoside, MIC/MICBI bakeng sa GICM2. ea Enterococcus ke 0.5～1μg/ml, 'me MIC ea Enterococcus e hanyetsanang le lithibela-mafu tsa glycopeptide ke 1～2μg/ml.
