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Caspofungin bakeng sa Tšoaetso ea Antifungal

Tlhaloso e Khutšoanyane:

Lebitso: Caspofungin

Nomoro ea CAS: 162808-62-0

Mokhoa oa molek'hule: C52H88N10O15

Boima ba molek'hule: 1093.31

Nomoro ea EINECS: 1806241-263-5

Sebaka se belang: 1408.1±65.0 °C (Ho Boletsoe esale pele)

Boima: 1.36±0.1 g/cm3(E boletsoeng esale pele)

Acidity coefficient: (pKa) 9.86±0.26 (E boletsoeng esale pele)


Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Lintlha tsa Sehlahisoa

Lebitso Caspofungin
Nomoro ea CAS 162808-62-0
Mokhoa oa limolek'hule Setšoantšo sa C52H88N10O15
Boima ba molek'hule 1093.31
Nomoro ea EINECS 1806241-263-5
Ntho e belang 1408.1±65.0 °C (E boletsoeng esale pele)
Botenya 1.36±0.1 g/cm3(E boletsoeng esale pele)
Acidity coefficient (pKa) 9.86±0.26 (E boletsoeng esale pele)

Litlhaloso tse tšoanang

CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy- L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650

Lintho tsa Lik'hemik'hale

Caspofungin e bile echinocandin ea pele e amohetsoeng bakeng sa kalafo ea mafu a fungal a hlaselang.Liteko tsa in vitro le in vivo li netefalitse hore caspofungin e na le tšebetso e ntle ea antibacteria khahlano le likokoana-hloko tsa bohlokoa tse nkang monyetla-Candida le Aspergillus.Caspofungin e ka senya lerako la sele ka ho thibela motsoako oa 1,3-β-glucan.Ka kakaretso, caspofungin e na le phello e ntle kalafong ea candidiasis le aspergillosis.

Phello

(1,3) -D-glucan synthase ke karolo ea bohlokoa ea fungal cell wall synthesis, 'me caspofungin e ka ba le phello ea antifungal ka ho se qothisane lehlokoa le enzyme ena.Kamora ho tsamaisoa ka methapo, khatello ea sethethefatsi sa plasma e theoha ka potlako ka lebaka la ho ajoa ha lisele, ho lateloa ke ho lokolloa butle-butle ha sethethefatsi liseleng.Metabolism ea caspofungin e ile ea eketseha ka tekanyo e ntseng e eketseha 'me e ne e amana le lethal dose ka nako ea boemo bo tsitsitseng ka litekanyetso tse ngata.Ka hona, e le ho finyella litekanyetso tse sebetsang tsa phekolo le ho qoba ho bokella lithethefatsi, tekanyo ea pele ea ho laela e lokela ho tsamaisoa e lateloa ke tekanyo ea tlhokomelo.Ha u sebelisa li-inducers tsa cytochrome p4503A4 ka nako e le 'ngoe, tse kang rifampicin, carbamazepine, dexamethasone, phenytoin, joalo-joalo, ho kgothaletswa ho eketsa tekanyo ea tlhokomelo ea caspofungin.

Lipontšo

Lipontšo tse amohelehang tsa FDA bakeng sa caspofungin li kenyelletsa: 1. Feberu e nang le neutropenia: e hlalosoa e le: feberu> 38 ° C e nang le palo e feletseng ea neutrophil (ANC) ≤500 / ml, kapa ka ANC ≤1000 / ml 'me ho boleloa esale pele hore e ka fokotseha. ka tlase ho 500 / ml.Ho ea ka khothatso ea Infectious Diseases Society of America (IDSA), le hoja bakuli ba nang le feberu e sa khaotseng le neutropenia ba 'nile ba phekoloa ka lithibela-mafu tse pharaletseng, bakuli ba kotsing e kholo ba ntse ba khothalletsoa ho sebelisa empiric antifungal therapy, ho akarelletsa le caspofungin le lithethefatsi tse ling tsa antifungal. ..2. Invasive candidiasis: IDSA e khothalletsa li-echinocandins (tse kang caspofungin) e le moriana oa khetho bakeng sa candidiasis.E ka boela ea sebelisoa ho alafa li-abscesses tse ka hare ho mpa, peritonitis le mafu a sefuba a bakoang ke tšoaetso ea Candida.3. Esophageal candidiasis: Caspofungin e ka sebelisoa ho phekola candidiasis ea esophageal ho bakuli ba nang le ho hanyetsa kapa ho se mamelle mekhoa e meng ea phekolo.Liphuputso tse 'maloa li fumane hore phello ea phekolo ea caspofungin e tšoana le ea fluconazole.4. Aspergillosis e hlaselang: Caspofungin e amohetsoe bakeng sa phekolo ea aspergillosis e hlaselang ho bakuli ba nang le ho se mamelle, ho hanyetsa, le ho se sebetse ha moriana o moholo oa antifungal, voriconazole.Leha ho le joalo, echinocandin ha e khothalletsoe e le phekolo ea pele.


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