Daptomycin 103060-53-3 bakeng sa mafu a tšoaetsanoang
Lintlha tsa Sehlahisoa
| Lebitso | Daptomycin |
| Nomoro ea CAS | 103060-53-3 |
| Mokhoa oa limolek'hule | C72H101N17O26 |
| Boima ba molek'hule | 1620.67 |
| Nomoro ea EINECS | 600-389-2 |
| Sebaka se qhibilihang | 202-204°C |
| Ntho e belang | 2078.2±65.0 °C (E boletsoeng esale pele) |
| Botenya | 1.45±0.1 g/cm3(E boletsoeng esale pele) |
| flash point | 87℃ |
| Maemo a polokelo | E koetsoe ka sehatsetsing, ka tlas'a -20°C |
| Solubility | Methanol: e qhibilihang ka 5mg/mL |
| Acidity coefficient | (pKa) 4.00±0.10 (E boletsoeng esale pele) |
| Sebopeho | phofo |
| Mmala | e se nang mmala ho isa bosehla bo fokolang |
Litlhaloso tse tšoanang
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-L-4-abuny) ;N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzola-Od-Odzoyl)]; ecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R) -3-methyl-L-α- glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Tlhaloso
Sethibela-mafu daptomycin ke lithibela-mafu tsa cyclic lipopeptide tse nang le sebopeho se secha se ntšitsoeng morong oa belisoa oa Streptomyces (S. reseosporus), e sitisang biosynthesis ea baktheria cell wall peptidoglycan ka ho sitisa ho tsamaisoa ha li-amino acid ka lera la sele. Ho fetola thepa ea lera la cytoplasmic ho ka sitisa lera la baktheria ka litsela tse ngata 'me ka potlako ho bolaea libaktheria tsa Gram-positive. Ntle le bokhoni ba eona ba ho sebetsana le libaktheria tse amanang le Gram-positive, daptomycin e bohlokoa haholo bakeng sa mefuta e ka thoko e bontšitseng ho hana methicillin, vancomycin, le linezolid in vitro. E na le ts'ebetso e matla, 'me thepa ena e na le litlamorao tsa bohlokoa tsa kliniki ho bakuli ba tšoaelitsoeng haholo. Eosinophilic pneumonia ke lefu le sa tloaelehang le le kotsi haholo le nang le matšoao a kenyeletsang feberu, ho khohlela, ho hema ka thata, le ho hema ka thata.
Phello ea Antibacterial
Daptomycin e na le ts'ebetso e ntle ea bacteriostatic khahlano le libaktheria tse fapaneng tse hananang le lithibela-mafu, joalo ka MIC=0.06-0.5 μg/ml bakeng sa Staphylococcus aureus (MRSA) e hanyetsanang le methicillin, le Staphylococcus aureus (MRSA) e hanyetsanang le methicillin. MIC=0.0625～1μg/ml bakeng sa baktheria, MIC=0.12～0.5μg/ml bakeng sa Staphylococcus epidermidis e hanyetsanang le oxacillin, MIC=2.5μg/ml bakeng sa enterococcus e hanyetsanang haholo le lithibela-mafu tsa aminoglycoside, MICmgr of the GBI = MICM2. Enterococcus ke 0.5～1μg/ml, mme MIC ea Enterococcus e hanyetsanang le lithibela-mafu tsa glycopeptide ke 1～2μg/ml.
