Capofungin bakeng sa tšoaetso ea antifungal
Lintlha tsa sehlahisoa
| Lebitso | Caspofungin |
| Nomoro ea CAS | 16280808-0 |
| Foromo ea limolecular | C52h88n10o15 |
| Boima ba Molecular | 1093.31 |
| Nomoro ea Einecs | 1806241-263-5 |
| Poleft Point | 1408.1 ± 65.0 ° C (e boletsoeng esale pele) |
| Letsoalo | 1.36 ± 0.1 g / cm3 (e boletsoeng esale pele) |
| Acidity cormety | (pka) 9.86 ± 0.26 (e boletsoeng esale pele) |
Synonyms
CS-1171; caspofungine; caspofungin; pnemphocinb0 21 - Amithyl) -Na -1-oxetotetrabecyl) -4-hydroxy-l-Ornithine] -5 - hydroxy-l-hydroxy-099; AIDS0585050; AIDS-058650
Li-commituri tsa lik'hemik'hale
Caspofutsane e ne e le Echinocandin ea pele e ile ea amohela kalafo ea tšoaetso ea fungal ea ntloaneng. Ho vitro le litheong tsa vivo li netefalitse hore caspofuusein e na le ts'ebetso e ntle ea likokoana-hloko khahlano le ho tšoanela menyetla ea bohlokoa e hlokang monyetla-bala-candgilgillas. Caspofungin e ka rurura lebota la sele ka ho thibela synthesis ea 1,3-β-glucan. Ka tleleniking, Casiffonglin e na le phello e ntle kalafong ea baetsi ba fapaneng le baspergillosis.
Phello
(1,3) -D-glucan sythase ke karolo ea bohlokoa ea lebota la selefouno, le caspofueng li ka tsoela pele ho thibela enzyme ea ho thibela enzyme. Kamora tsamaiso ea intravey, e oela ka potlako ka potlako ka lebaka la ho tsamaisoa ha lithethefatsi, e lateloang ka mokhoa o khothalletsoang butle-butle tunse ho tsoa tishu. Metabolism ea caspofulung e ile ea eketseha ka tekanyetso e matla 'me e ne e amana le tekano nakong ea ho tsitsipana le litekanyetso tse ngata. Ka hona, molemong oa ho fihlela maemo a sebetsang a sebetsang le ho qoba ho bokella lithethefatsi, tekanyetso ea pele ea ho jala e lokela ho tsamaisoa ka tekanyetso ea tlhokomelo. Ha o sebelisa cytoctrome p4503a4 o kopantsoe ka nako e ts'oanang, carbamazepe, dexamethasone, jhenytoin, e joalo.
Matšoao
Matšoao a e amohetseng a caspofungo Cons: Ho latela litlhahiso tsa mafu a tšoaetsanoang a Amerika (Sechaba), leha ba sentse se tšoeroe ke caspofunaeli le lithethefatsi tse ling tse thibetsoeng. . 2. Litšoantšo tse hlaselang: IDSA e khothaletsa Echinocandins (joalo ka caspofungoliin) e le moriana oa boikhethelo bakeng sa Campide. E ka sebelisoa hape ho phekola li-absSeba tsa ka mpeng, likonteraka tsa sefuba tse bakoang ke ts'oaetso ea Candida. 3. Esophageal Pididias: Caspofutsane e ka sebelisoa ho phekola mokhethoa oa esophageal ho bakuli ba nang le pheko kapa phetiso ho mekhoa e meng. Boithuto bo 'maloa bo fumane hore phehetso ea kalafo ea caspopung e bapisoa le ea fecconazole. 4. Kamore e hlasetsoeng: e amohetsoe kalafo ea bakuli ba sa khaotseng, ho hanyetsa sethunya sa antifungal, Voricoonazole. Leha ho le joalo, Echinocandin ha e khothalletsoe e le kalafo ea mola oa pele.
