Atosiban Acetate E Sebelisitsoe ho Tsoaloa Pele ho Pele ho Nako
Lintlha tsa Sehlahisoa
| Lebitso | Atosiban |
| Nomoro ea CAS | 90779-69-4 |
| Mokhoa oa limolek'hule | Setšoantšo sa C43H67N11O12S2 |
| Boima ba molek'hule | 994.19 |
| Nomoro ea EINECS | 806-815-5 |
| Ntho e belang | 1469.0±65.0 °C (E boletsoeng esale pele) |
| Botenya | 1.254±0.06 g/cm3(E boletsoeng esale pele) |
| Maemo a polokelo | -20°C |
| Solubility | H2O:≤100 mg/mL |
Tlhaloso
Atosiban acetate ke disulfide-bonded cyclic polypeptide e nang le 9 amino acid. Ke molek'hule ea oxytocin e fetotsoeng maemong a 1, 2, 4 le 8. N-terminus ea peptide ke 3-mercaptopropionic acid (thiol le Sehlopha sa sulfhydryl sa [Cys] 6 se etsa setlamo sa disulfide), C-terminal e ka sebōpeho sa amide, amino acid ea bobeli ke e-D-terminal ea D-terminal (D-terminal) le atosiban acetate e sebelisoa meriana e le asene E teng ka mokhoa oa letsoai la acid, le tsejoang ka hore ke atosiban acetate.
Kopo
Atosiban ke mohanyetsi oa oxytocin le vasopressin V1A e kopantsoeng ea li-receptor, mokelikeli oa oxytocin o tšoana ka sebopeho le vasopressin V1A receptor. Ha mokelikeli oa oxytocin o koetsoe, oxytocin e ntse e ka sebetsa ka V1A receptor, kahoo hoa hlokahala ho thibela litsela tse peli tse ka holimo tsa li-receptor ka nako e le 'ngoe,' me khanyetso e le 'ngoe ea receptor e le' ngoe e ka thibela ka katleho ho thibela popelo. Lena hape ke le leng la mabaka a ka sehloohong a etsang hore li-agonists tsa β-receptor, calcium channel blockers le prostaglandin synthase inhibitors li se ke tsa thibela ka katleho li-contraction tsa uterine.
Phello
Atosiban ke mohanyetsi o kopantsoeng oa li-receptor tsa oxytocin le vasopressin V1A, sebopeho sa eona sa lik'hemik'hale se tšoana le tse peli, 'me se na le kamano e phahameng bakeng sa li-receptors,' me se hlōlisana le li-receptor tsa oxytocin le vasopressin V1A, kahoo li thibela tsela ea liketso tsa oxytocin le vasopressin le ho fokotsa li-contraction tsa uterine.
