Vardenafil Dithydroclorvid o ile a phekola Equintile Dysfunction 224785-9-5
Lintlha tsa sehlahisoa
| Lebitso | Vardenaafal Dilydrokedide |
| Nomoro ea CAS | 224785-90-4 |
| Foromo ea limolecular | C23h32n6o4s |
| Boima ba Molecular | 488.6 |
| Nomoro ea Einecs | 607-0888-5 |
| Ntlha ea ho qhibiliha | 230-235 ° C |
| Letsoalo | 1.37 |
| Boemo ba polokelo | E tiisitsoeng ka ho omella, e boloketsoe Mahala a lazerzer, ka tlase ho Cels -20 ° C |
| Foromo | Phofo |
| Mmala | Tšoeu |
| Acidity cormety | (pka) 9.86 ± 0.20 (e boletsoeng esale pele) |
Synonyms
Vardenaafree 5- (4-Ethylpiiperazin-1-sulfonyl) Phenyl) -5-methyl-7-Phenyl-7-Phenyl-7-Peo-F) (One 1,2,4). VardenafalhyhyhyhyhyhyhyhyhyhlHelyhyhyLhdradetrity19%; VardenafyhyhyhyhyhyhyhyhyhyhyhyLidertriedrah Cas Bahlahisi ba ikemetseng -lhalyhyhyhyhyhyhyhylorite methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazinehydrochloridetrihydrate
Phello ea pharmaColoCologana
PUSELETSO EA MAHALA
Setlhare sena ke mofuta oa phosphodiestese 5 (pde5) inhibito. Tsamaiso ea Setlhare sena e ka ntlafatsa boleng le nako ea ho phomola le ho ntlafatsa katleho ea thobalano le bakuli ba banna ba nang le mathata a banna. Pono le tlhokomelo ea sebaka sa Pence e amana le ho phomola ha lisele tsa cavernosal, le cymp, lisele tsa mesifa ea cavernosal hantle. Setlhare sena se thibela ho bolaoa ha CGP ka ho thibela mofuta oa 5, ka lebaka leo a etsa hore mesifa e mele ea CGP, e phutholoha ha mesifa e boreleli ea cavernosum ea Corpus, le liketsahalo tsa botoneng. Ha e bapisoa le Phosphodiames 1, 2, 4, 4, sethethefatsi sena se na le tsebo e phahameng bakeng sa mofuta oa 5 Phosphodiesterase. Lintlha tse ling li bontša hore phello ea eona ea ho ikhethela le e santhiji ea hau ho phosphodiesterase 5 e molemo ho feta tse ling tsa phosphodioterase 5 inhibitors. Mofuta oa phosphodiatsise inhibitors o fokola.
Melemo le likopo
1. Ha e sebelisoa hammoho ka lithibela-pele (joalo ka rithinavir, saquinavir, ketoconazole, erythromycin, e jj.) Fypotension, liphetoho tse bonoang, tse bonoang, hlooho ea hlooho ea sefahleho, sefahleho sa sefahleho sa sefahleho sa sefahleho). Setlhare sena se lokela ho qojoa hammoho le Ritinavir le Indinavir. Ha e sebelisoa hammoho le erythromrycin, ketoconaznazole, tekanyetso ea lithethefatsi ena ha ea lokela ho feta 5 mg, keseraconazole ha ea lokela ho feta 200 mg.
2. Bakuli ba nka li-nitrate kapa ba amohela pherekano ea " Mochini oa eona oa ketso o ho eketsa hapeTLHOKOMELISO CGP, e bakiloeng ka phello e matlafatsang a ammehlperper le sekhahla sa pelo e eketsehileng. Ha e sebelisoa hammoho le li-blockers tsa α-roceptor, e ka ntlafatsa phello e amme le ho etella pele ho hypotents. Ka hona, tšebeliso ea lithethefatsi tsena e thibetsoe ba sebelisang li-blocked tsa α-roceptor. Lijo tse nang le mafura a mahareng (30% ea likhalori tse mafura) e ne e se na phello e kholo ho pharmacokikitics ea lithethefatsi tsena, le ho jala malinyane a mangata (ho feta tekanyetso ea mafura a maholo.
Pharmacokinetics
E kenelletse ka potlako ka mor'a tsamaiso ea molomo, biana e felletseng ea table ea molomo ke 15%, le nako ea ho ba 1h (0.5 (0.5 (0.5). Tharollo ea molomo oa 10mg kapa 20mg, nako ea tlholeho e tloaelehileng ke 0.9H le 0.7H, ka kakaretso, ka ho latellana le nako ea phello ea lithethefatsi e ka fihlela 1H. Tempen e tlamang ea lihlahla tsa lithethefatsi tsena e ka ba 95%. 1.5H kamora hore tekanyetso e le 'ngoe ea molomo ea 20 mg, litaba tsa lithethefatsi tse semen ho semen ke 0,00018% ea tekanyetso. Setlhare se ne se le metabonod in the male ke cytochrome p450 (cyP) 3a4, 'me tekanyo e nyane e metaeli ka cyp 3a59 isoenzyme. Moana ea ka Sehloohong Metabolite ke M1 e thehiloeng ke khethollo ea sebopeho sa litho tsa Piperarone. M1 Hape e boetse e na le phello ea ho thibela phosphodiesterase 5 (hoo e ka bang 7% ea katleho e felletseng), 'me khatello ea mali e ka ba 26% ea khatello ea mali. , 'me e ka ba metaboso e eketsehileng hape. Likarolo tsa Tlhahlobo tsa Lithethefatsi ka mokhoa oa metabolitates ka li-metabotoli tse ka bang 91% ho 95% le 2% ho isa ho 6% ho isa ho 6% ho isa ho 6% Sekhahla ka kakaretso ke 56 l ka hora, 'me halofo ea bophelo ba motsoali le M1 kaofela ke lihora tse 4 ho isa ho tse 5 ho isa ho tse 5 ho isa ho tse 5 ho isa ho tse 5.
