Tirzepatide

Tirzepatide API
Tirzepatide ke "groundbreaking synthetic peptide" e sebetsang e le li-agonists tse peli tse itšetlehileng ka tsoekere ea insulinotropic polypeptide (GIP) le glucagon-like peptide-1 (GLP-1) receptors. E emela sehlopha se secha sa liphekolo tse thehiloeng ho incretin tse tsejoang e le "twincretins", tse fanang ka taolo e ntlafalitsoeng ea metabolic ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le botenya.

API ea rona ea Tirzepatide e hlahisoa ka mekhoa e tsoetseng pele ea ho kopanya lik'hemik'hale, ho netefatsa bohloeki bo phahameng, maemo a litšila a tlase, le ts'ebetso e ntle ea batch-to-batch. Ho fapana le li-peptide tse nkiloeng ho rDNA, API ea rona ea maiketsetso ha e na liprotheine tsa lisele tse amohelang le DNA, e ntlafatsang haholo ts'ebetso ea ts'ireletso le taolo ea taolo. Ts'ebetso ea tlhahiso e ntlafalitsoe hore e eketsehe ho fihlela tlhoko e ntseng e hola ea lefats'e.

Mokhoa oa Ts'ebetso
Tirzepatide e sebetsa ka nako e le 'ngoe e hlasimolla li-receptor tsa GIP le GLP-1, e fana ka litlamorao tse tlatselletsang le tsa synergistic:

GIP receptor activation: e ntlafatsa secretion ea insulin mme e ka ntlafatsa kutloisiso ea insulin.

Ts'ebetso ea GLP-1 receptor: e hatella ho lokolloa ha glucagon, e liehisa ho tsoa ka mpeng, 'me e fokotsa takatso ea lijo.

Ts'ebetso e kopaneng e lebisa ho:

Taolo e ntlafetseng ea glycemic

Ho fokotseha ha boima ba 'mele

Ho khora ho matlafatsa le ho fokotsa ho ja lijo

Lipatlisiso tsa Tleliniki le Liphetho
Tirzepatide e bonts'itse katleho e e-so ka e bonoa litekong tse ngata tse kholo tsa bongaka (SURPASS & SURMOUNT letoto):

Phokotso e phahameng ea HbA1c ha e bapisoa le GLP-1 RAs (mohlala, Semaglutide)

Ho lahleheloa ke boima ba 'mele ho fihlela ho 22.5% ho bakuli ba batenya - ho bapisoa le ho buuoa ka bariatric maemong a mang

Ho qala ka potlako ea phello le taolo e tšoarellang ea glycemic holim'a ts'ebeliso ea nako e telele

Matšoao a ntlafalitsoeng a cardiometabolic: ho kenyelletsa khatello ea mali, lipids, le ho ruruha

Tirzepatide ha e fetole feela paradigm ea kalafo bakeng sa lefu la tsoekere la mofuta oa 2 empa hape e hlaha e le khetho e kholo ea kalafo bakeng sa tahlehelo ea boima ba 'mele le lefu la metabolic.

Boleng & Tumellano
API ea rona ea Tirzepatide:

E kopana le maemo a lefats'e a boleng (FDA, ICH, EU)

E lekoa ka HPLC bakeng sa maemo a tlase a litšila tse tsejoang le tse sa tsejoeng

E entsoe tlasa maemo a GMP ka litokomane tse felletseng tsa ts'ebetso

Ts'ehetsa tlhahiso e kholo ea R&D