Sildenafil Citrate Ho Phekola Erectile Dysfunction 171599-83-0
Lintlha tsa Sehlahisoa
| Lebitso | Sildenafil Citrate |
| Nomoro ea CAS | 171599-83-0 |
| Mokhoa oa limolek'hule | C28H38N6O11S |
| Boima ba molek'hule | 666.70 |
| Nomoro ea EINECS | 200-659-6 |
| Merck | 14,8489 |
| Botenya | 1.445g/cm3 |
| Boemo ba polokelo | 2-8°C |
| Sebopeho | Phofo |
| Mmala | Bosoeu |
| Ho qhibiliha ha metsi | DMSO: >20mg/mL |
Litlhaloso tse tšoanang
Viagra, Sildenafil citrate; 1- [[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl] -4-methylpiperazinecitratesalt; 5- [2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratesalt; 1- [[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl] -4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate(100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate, Litsebi tsa phepelo; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl] -1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Phello ea Pharmacological
Ketso ea Pharmacological
Sildenafil citrate ke khetho ea 5-phosphodiesterase inhibitor e ntlafatsang nitric oxide-dependent, cyclic guanosine monophosphate-mediated pulmonary vasodilation ka ho thibela ho senyeha ha cyclic guanosine monophosphate. Ntle le ho atolosoa ka ho toba ha methapo ea mali ea pulmonary, e ka boela ea thibela kapa ea fetola ho tsosolosoa ha methapo ea mali.
Thepa ea Meriana le Lisebelisoa
Sildenafil citrate, lebitso la khoebo la Viagre, le tsejoang ka hore ke Viagra, ke cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE5) inhibitor e ka ntlafatsang erection ka mor'a tsamaiso ea molomo. Sildenafil citrate e ka ntlafatsa phello ea nitric oxide (NO) ka ho thibela mofuta oa 5 phosphodiesterase o senyang cyclic guanosine monophosphate (cGMP) ho corpus cavernosum. Eketsa boemo ba cGMP ho corpus cavernosum, phomotsa mesifa e boreleli ka har'a corpus cavernosum, eketsa ho phalla ha mali, ho lelefatsa nako ea ho emisa botona le ho eketsa ho tiea. Bakeng sa bakuli ba nang le bothata ba ho se sebetse hantle ha erectile. Batho ba baholo ba nka 50 mg ka molomo nako le nako, ho fihlela 1 nako ka letsatsi, 'me ba e sebelise ha ho hlokahala hoo e ka bang 1 hora pele ho thobalano. Chelete e phahameng ka ho fetisisa ke 0.1g nako le nako.
Lithuto tsa in vivo
Lintja tse nang le anesthetized, Sildenafil citrate e ntlafatsa mosebetsi oa penile erectile tlas'a tšusumetso ea methapo ea pelo ka ho lekanya khatello ea intracavernous. Sildenafil citrate e ile ea khutlisa khatholoho e tsosolositsoeng ea carbamoylcholine ka mokhoa o hlakileng le e thibelang sebopeho sa superoxide liseleng tsa cavernosal tsa mebutlanyana ea hypercholesterolemic. Likhotong tsa Sprague-Dawley, Sildenafil e ntlafatsa mosebetsi oa erectile ka mokhoa o itšetlehileng ka tekanyo ea nako, ka ho hlaphoheloa ho hoholo ho etsahala ka letsatsi la 28 ka tekanyo ea 20 mg / kg ka letsatsi. Likhotong tsa Sprague-Dawley, tsamaiso ea Sildenafil e ile ea fella ka ho boloka karo-karolelano ea mesifa ea collagen le ho boloka CD31 le polelo ea eNOS. Likhotong tsa Sprague-Dawley, Sildenafil e fokolitse haholo palo ea apoptotic mme e eketsa phosphorylation ea akt le eNOS ha e bapisoa le sehlopha sa taolo.
