Lisebelisoa tsa Pharma
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Fmoc-Ls(Pal-Glu-OtBu)-OH
Fmoc-Ls(Pal-Glu-OtBu) -OH ke mohaho o khethehileng oa lipidated amino acid o etselitsoeng ho kopanya peptide-lipid. E na le lysine e sirelelitsoeng ke Fmoc e nang le ketane ea mahlakoreng ea palmitoyl-glutamate, e matlafatsang kamano ea lera le bioavailability.
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Fmoc-Hae-Aib-OH
Fmoc-His-Aib-OH ke letlapa la moaho la dipeptide le sebelisoang ho kopantseng peptide synthesis, ho kopanya Fmoc-protected histidine le Aib (α-aminoisobutyric acid). Aib e hlahisa conformational rigidity, e etsa hore e be ea bohlokoa bakeng sa ho rala li-peptide tsa helical le tse tsitsitseng.
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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH ke sekhechana se sirelelitsoeng sa tetrapeptide se sebelisoang ho peptide synthesis le nts'etsopele ea lithethefatsi. E na le lihlopha tse sebetsang tse sirelelitsoeng ka mokhoa o hlophisitsoeng bakeng sa ho kopanya ka mehato le likarolo tsa Aib (α-aminoisobutyric acid) ho matlafatsa botsitso ba helix le conformational rigidity.
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU ke molek'hule ea maiketsetso ea lipidated linker e etselitsoeng phano ea lithethefatsi le li-antibody-drug conjugates (ADCs). E na le mohatla oa stearoyl (Ste) hydrophobic, γ-glutamyl targeting motif, AEEA spacers bakeng sa ho feto-fetoha ha maemo, le sehlopha sa OSu (NHS ester) bakeng sa ho kopanya hantle.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH ke mohaho oa maiketsetso o sirelelitsoeng oa tripeptide o nang le leucine ea α-methylated, e atisang ho sebelisoa ho moralo oa lithethefatsi tsa peptide ho matlafatsa botsitso ba metabolism le khetho ea ho amohela.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) ke sesepa sa maiketsetso sa zwitterionic se sebelisoang haholo lipatlisisong tsa protheine ea membrane le biology ea meralo, haholo ho spectroscopy ea NMR le crystallography.
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Donidalorsen
Donidalorsen API ke antisense oligonucleotide (ASO) e ntseng e etsoa lipatlisiso bakeng sa phekolo ea angioedema ea lefutso (HAE) le maemo a amanang le ho ruruha. E ithutoa moelelong oa liphekolo tse lebisitsoeng ho RNA, ka sepheo sa ho fokotsa polelo eaplasma prekallikrein(KLKB1 mRNA). Bafuputsi ba sebelisa Donidalorsen ho hlahloba mekhoa ea ho khutsisa liphatsa tsa lefutso, pharmacokinetics e itšetlehileng ka tekanyo, le taolo ea nako e telele ea ho ruruha ha bradykinin.
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"Fitusiran"
Fitusiran API ke RNA e nyane e sitisang e nyane (siRNA) e batlisisitsoeng haholo-holo lebaleng la mathata a haemophilia le a coagulation. E lebisitse hoantithrombin (AT kapa SEPINC1)liphatsa tsa lefutso sebeteng ho fokotsa tlhahiso ea antithrombin. Bafuputsi ba sebelisa Fitusiran ho hlahloba mekhoa ea ho kena-kenana le RNA (RNAi), ho khutsisa liphatsa tsa lefutso ka sebete, le mekhoa e mecha ea phekolo ea ho leka-lekanya coagulation ho bakuli ba hemophilia A le B, ba nang le li-inhibitors kapa ba se na tsona.
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Givosiran
Givosiran API ke RNA e nyane e sitisang e nyane (siRNA) e ithutoang bakeng sa kalafo ea acute hepatic porphyria (AHP). E shebane ka ho khetheha leALAS1gene (aminolevulinic acid synthase 1), e amehang tseleng ea heme biosynthesis. Bafuputsi ba sebelisa Givosiran ho batlisisa mekhoa ea phekolo e thehiloeng ho RNA (RNAi), ho khutsisa liphatsa tsa lefutso tse lebisitsoeng ho sebete, le ho feto-fetoha ha mekhoa ea metabolic e amehang ho porphyria le mathata a amanang le lefutso.
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Plozasiran
Plozasiran API ke RNA e nyane e sitisang e nyane (siRNA) e ntlafalitsoeng bakeng sa kalafo ea hypertriglyceridemia le mathata a amanang le pelo le metabolic. E lebisitse hoAPOC3gene, e kenyelletsang apolipoprotein C-III, e laolang metabolism ea triglyceride. Lipatlisisong, Plozasiran e sebelisetsoa ho ithuta maqheka a theolang lipid a thehiloeng ho RNAi, ho khetholla liphatsa tsa lefutso, le phekolo ea nako e telele bakeng sa maemo a kang malapa a chylomicronemia syndrome (FCS) le dyslipidemia e tsoakiloeng.
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Zilebesiran
Zilebesiran API ke lipatlisiso tse nyane tse sitisang RNA (siRNA) tse ntlafalitsoeng bakeng sa kalafo ea khatello ea mali. E lebisitse hoAGTgene, e kenyang angiotensinogen-e leng karolo ea bohlokoa ea renin-angiotensin-aldosterone system (RAAS). Lipatlisisong, Zilebesiran e sebelisetsoa ho ithuta mekhoa ea ho khutsisa liphatsa tsa lefutso bakeng sa taolo ea nako e telele ea khatello ea mali, theknoloji ea ho fana ka RNAi, le karolo e pharaletseng ea tsela ea RAAS ho mafu a pelo le a renal.
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Caspofungin bakeng sa mafu a antifungal
Lebitso: Caspofungin
Nomoro ea CAS: 162808-62-0
Mokhoa oa molek'hule: C52H88N10O15
Boima ba molek'hule: 1093.31
Nomoro ea EINECS: 1806241-263-5
Sebaka se belang: 1408.1±65.0 °C (Ho Boletsoe esale pele)
Boima: 1.36±0.1 g/cm3(E boletsoeng esale pele)
Acidity coefficient: (pKa) 9.86±0.26 (E boletsoeng esale pele)