MOTS-C

Tlhaloso e Khutšoanyane:

MOTS-C API e hlahisoa tlas'a maemo a thata a kang a GMP ho sebelisoa theknoloji e tiileng ea "peptide synthesis" (SPPS) ho netefatsa boleng ba eona bo phahameng, bohloeki bo phahameng le botsitso bo phahameng bakeng sa lipatlisiso le tšebeliso ea phekolo.
Likarolo tsa Sehlahisoa:

Bohloeki ≥ 99% (e tiisitsoe ke HPLC le LC-MS),
Endotoxin e tlase le lintho tse setseng tsa solvent,
E hlahisitsoe ho latela liprothokholo tsa ICH Q7 le GMP,
E ka fihlela tlhahiso e kholo, ho tloha ho li-batch tsa R&D tsa boemo ba milligram ho isa phepelong ea khoebo ea boemo ba gram le kilogram.

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

MOTS-C API

MOTS-C(Mitochondrial Open Reading Frame ea 12S rRNA Type-c) ke 16-amino acid.peptide e nkiloeng ke mitochondria (MDP)e kentsoeng ke genome ea mitochondrial. Ho fapana le li-peptide tsa khale tse kentsoeng ka nyutlelie, MOTS-c e tsoa sebakeng sa 12S rRNA sa DNA ea mitochondrial mme e bapala karolo ea bohlokoa hoe laola metabolism ea cellular, karabelo ea khatello ea maikutlo, le kutloisiso ea insulin.

Joalo ka peptide e ncha ea kalafo,MOTS-c APIe fumane thahasello e kholo mafapheng amathata a metabolism, botsofali, physiology ea boikoetliso, le meriana ea mitochondrial. Peptide ha joale e ntse e le tlas'a lipatlisiso tse matla 'me e nkoa e le motho ea tšepisangmoloko o latelang oa phekolo ea peptidee lebisa tlhokomelo ho bophelo bo botle ba metabolism le bophelo bo bolelele.

Mokhoa oa Ts'ebetso

MOTS-c e hlahisa litlamorao tsa eona ka homitochondrial-nuclear cross-talk- mokhoa oo mitochondria e buisanang le khubu ho boloka homeostasis ea cellular. Peptide e fetisoa ho tloha mitochondria ho ea khubung ka lebaka la khatello ea maikutlo, moo e sebetsang e letaolo ea metabolismka ho susumetsa tlhahiso ea liphatsa tsa lefutso.

Mekhoa ea mantlha ea baeloji e kenyelletsa:

Tšebeliso ea AMPK (AMP-activated protein kinase):MOTS-c e hlasimolla AMPK, e leng setsi sa motlakase se bohareng, se khothaletsangho nkeloa ha tsoekere, mafura a acid oxidation, le biogenesis ea mitochondrial.
Ho eketsa kutloisiso ea insulin:MOTS-c e eketsa karabelo ea insulin ho mesifa le lisele tsa adipose, ho ntlafatsaglucose homeostasis.
Khatello ea oxidative le ho ruruha:Ka ho fetola tekano ea redox ea lisele le litsela tsa matšoao a ho ruruha.
Taolo ea ts'ebetso ea mitochondrial le biogenesis:E tšehetsa bophelo bo botle ba mitochondrial, haholo-holo tlas'a khatello ea maikutlo kapa maemo a botsofali.

Lipatlisiso tsa Phekolo le Liphello tsa Likokoana-hloko

Boithuto ba preclinical bo bonts'itse litlamorao tse fapaneng tsa 'mele le kalafo tsa MOTS-c ho mehlala ea in vitro le ea liphoofolo:

1. Mathata a Metabolic (Botenya, Mofuta oa 2 oa Lefu la tsoekere, Ho hanyetsa insulin)

E ntlafatsa mamello ea glucose mme e theola boemo ba tsoekere maling
E matlafatsakutloisiso ea insulinntle le ho eketsa maemo a insulin
Phatlalatsotahlehelo ea boima ba 'mele le ho oxidation ea mafuraho litoeba tse nonneng tse bakoang ke lijo

2. Anti-botsofali le ho phela nako e telele

Maemo a MOTS-c a fokotseha ka lilemo, 'me tlatsetso ho litoeba tse tsofetseng ho bontšitsoe hoeketsa matla a mmele, ntlafatsa ts'ebetso ea mitochondrial, leho lieha ho fokotseha ho amanang le lilemo.
E ntlafatsa ts'ebetso ea boikoetliso lemamello ea mesifaka ho ntlafatsa metabolism ea oxidative.

3. Tšireletso ea Mitochondrial le Cellular Stress

E matlafatsaho phela ha cellular tlas'a khatello ea metabolism kapa oxidativemaemo.
E eketsa tlhahiso ea liphatsa tsa lefutso tse amanang letokiso ea cellular le autophagy.

4. Matla a pelo le methapo ea mali

Lithuto tsa pele li fana ka maikutlo a hore MOTS-c e ka sireletsalisele tsa vascular endothelialle ho fokotsa matšoao a khatello ea pelo.
Lintho tse ka bang teng tsa neuroprotective kaanti-inflammatory le antioxidative litselali ntse li etsoa lipatlisiso.

API Manufacturing le Litšobotsi tsa Boleng

At Sehlopha sa Gentolex, ronaMOTS-c APIe etsoa ka ho sebelisasolid-phase peptide synthesis (SPPS)tlasa maemo a thata a kang a GMP, ho netefatsa boleng bo holimo, bohloeki, le botsitso bakeng sa lipatlisiso le ts'ebeliso ea kalafo.