Ipamorelin
Ipamorelin API
Ipamorelin ke hormone ea ho hōla ha pentapeptide e hlahisang peptide (GHRP) e entsoeng ka li-amino acid tse hlano (Aib-His-D-2-Nal-D-Phe-Ls-NH₂). Ke khetho ea GHSR-1a agonist e nang le bokhoni ba ho susumetsa tlhahiso ea hormone (GH) e nang le boitsebiso bo phahameng. Ha ho bapisoa le li-GHRP tsa pejana (tse kang GHRP-2 le GHRP-6), Ipamorelin e bontša khetho e ntle, polokeho le botsitso ba meriana ntle le ho ama haholo maemo a lihomone tse ling tse kang cortisol, prolactin kapa ACTH.
E le API ea peptide e nkoang e le ea bohlokoa haholo, Ipamorelin hajoale e sebelisoa haholo lipatlisisong tse khahlanong le botsofali, ho tsosolosoa ha lipapali, ho kenella ha masapo, ho hlaphoheloa ka mor'a ho sebetsa le ho laola tšebetso ea metabolic.
Patlisiso le Mokhoa oa Ts'ebetso
Ipamorelin e khothalletsa ho lokolloa ha hormone ea ho hōla ha endogenous (GH) ho tloha ho anterior pituitary ka ho khetha ho kenya li-hormone secretion receptor (GHSR-1a) le ho etsisa ketso ea ghrelin. Mekhoa ea eona ea mantlha ea pharmacological e kenyelletsa:
1. Hlahisa tlhahiso ea GH
Ipamorelin e natefeloa haholo ke GHSR-1a, e etsa hore tšoelesa ea pituitary e lokolle GH ntle le ho ama ACTH kapa maemo a cortisol haholo, 'me e na le tšireletso e ntle ea endocrine.
2. Ntlafatsa protheine synthesis le ho lokisa lisele
Ka ho eketsa litekanyo tsa IGF-1, e khothalletsa mesifa ea lisele tsa anabolism, e ntlafatsa ho lokisoa le ho tsosolosoa ha lisele, 'me e loketse ho lokisoa ha mahlomola, ho hlaphoheloa ha opereishene le phekolo ea anti-atrophy ea mesifa.
3. Ntlafatsa metabolism le kabo ea mafura
GH e na le litlamorao tsa ho bokella mafura le ntlafatso ea kutloisiso ea insulin. Ipamorelin e ka thusa ho laola boemo ba metabolism 'me e sebelisoa ho etsa lipatlisiso ka lefu la metabolism le ho kenella ka botenya.
4. Ntlafatsa ho teteana ha masapo le ho thibela botsofali
GH / IGF-1 axis e ka khothalletsa ho thehoa ha masapo le mineralization. Ipamorelin e bonts'a ts'episo ea anti-osteoporosis, ho tsosolosoa ha fracture le ho thibela botsofali.
5. Ntlafatsa morethetho oa circadian le boleng ba boroko
Ho lokolloa ha GH hangata ho tsamaisana le boroko bo tebileng. Liphuputso li fumane hore Ipamorelin e ka ntlafatsa ka tsela e sa tobang sebopeho sa boroko le ho ntlafatsa bokhoni ba ho hlaphoheloa ha 'mele.
Lithuto tsa preclinical le netefatso ea katleho
Le hoja e ntse e le setsing sa pele / sa pele sa kliniki, Ipamorelin e bontšitse tšireletso e ntle le katleho ho liphoofolo le lithuto tse ling tsa batho:
Maemo a GH a eketseha haholo (tlhōrō ka hare ho metsotso e 30, e tšoarella lihora tse 'maloa)
Ha ho na phello e hlakileng ea pro-cortisol kapa pro-ACTH, liphello tsa endocrine li ka laoleha haholoanyane
Ntlafatsa mesifa le matla (haholo-holo mefuteng ea liphoofolo tse tsofetseng)
Ntlafatsa ho hlaphoheloa ka mor'a ho buuoa le lebelo la ho lokisa lisele
Ho eketseha ha maemo a IGF-1 ho thusa ho lokisa lisele le karabelo ea antioxidant
Ho phaella moo, Ipamorelin e kopantsoe le li-mimetics tse ling tsa GHRH (tse kang CJC-1295) liphuputsong tse ling li bontšitse liphello tsa synergistic, tse ntlafatsang ho lokolloa ha pulse ea GH.
Tlhahiso ea API le netefatso ea boleng
Ipamorelin API e fanoeng ke Sehlopha sa rona sa Gentolex e lokiselitsoe ho sebelisa mokhoa o phahameng oa ** solid phase peptide synthesis process (SPPS) **, 'me e hloekisoa ka thata le ho lekoa ka boleng, e loketseng bakeng sa lipatlisiso tsa saense le nts'etsopele le tšebeliso ea liphaephe tsa pele tsa lik'hamphani tsa meriana.
Likarolo tsa sehlahisoa li kenyelletsa:
Bohloeki ≥99% (tlhahlobo ea HPLC)
Ha ho na endotoxin, solvent e tlase e setseng, tšilafalo ea tšepe e tlase
Fana ka sete e feletseng ea litokomane tsa boleng: COA, tlaleho ea boithuto ba botsitso, tlhahlobo ea mahlaseli a litšila, joalo-joalo.
Phepelo ea boemo ba gram ~ kilogram-level
