CJC-1295

CJC-1295 API

CJC-1295ke analogue ea peptide ea maiketsetso, e fetotsoeng ea tetra eaHormone ea ho hōla e lokollang (GHRH), e etselitsoeng hosusumetsa le ho boloka secretion ea endogenous growth hormone (GH). Ho fapana le GHRH ea matsoalloa, e nang le halofo ea bophelo bo khuts'oane, CJC-1295 e kenyelletsa aTheknoloji ea Drug Affinity Complex (DAC)., e lumellang hore e tlamahane ka kopanelo ho albumin maling lelelefatsa halofo ea bophelo ba eona ho feta matsatsi a 8. Popontshwa ena e etsa hore CJC-1295 aanalogue ea nako e telele ea GHRHe nang le bokhoni bo boholo hoanti-botsofali, khaello ea kholo, taolo ea metabolism, mathata a ho senya mesifa, le meriana ea ho tsosolosa.

Mokhoa oa Ts'ebetso

CJC-1295 e sebetsa hoGHRH receptore lutseng liseleng tsa somatotropic karolong e ka pele ea pituitary. Ts'ebetso ea eona ea tlhaho e tšoana le ea GHRH ea tlhaho, empa ka halofo ea bophelo e atolositsoeng haholo ka lebaka la phetoho ea DAC. Ketso ena e tsitsitseng e thusatokollo e tsitsitseng ea pulsatile ea GHle tlhahiso e eketsehileng eaInsulin-like growth factor 1 (IGF-1).

Mekhoa ea bohlokoa e kenyelletsa:

• Ho tsosoa ha secretion ea endogenous GH

• Phahamiso ea nako e telele ea maemo a IGF-1, ho tšehetsa liphello tsa anabolic

• Ha ho desensitization ea bohlokoakapa ho theola taolo ka tshebediso e tswellang

• Lipolysis e ntlafalitsoeng, protheine synthesis, le nchafatso ea lisele

Ka ho hlahisa 'mele oa GH le IGF-1 litsela, CJC-1295 e qoba litšitiso tse ngata tse amanang le phekolo ea GH e tsoang linaheng tse ling, tse kang receptor deensitization le mathata a polokeho.

Patlisiso ea Phekolo le Matla a Meriana

1. Khaello ea Hormone ea Khōlo (GHD)

Litekong tsa pele tsa kliniki, CJC-1295 e bontšitse:

• Keketseho e tsitsitsengGHleIGF-1maemo ho fihlela ho6-10 matsatsika mor'a ente e le 'ngoe

• Fokotsoemaqhubu a enteha e bapisoa le li-analogue tsa GHRH tsa letsatsi le letsatsi kapa liente tsa GH

• Ntlafatso ea ho latela mokuli le botsitso ba lihormone

2. Sebopeho sa 'Mele le Polokeho ea Mesifa

Lithuto tsa liphoofolo le batho li bontšitse hore CJC-1295:

• Phatlalatsoho fokola ha mesifalee fokotsa mafura a 'mele, haholo-holo mafura a visceral

• E matlafatsaho boloka naetrojene le protheine synthesiska mesifa ya marapo

• E ka thusa ho hlaphoheloa ho tlohalefu la sarcopeniale maemo a ho senya mesifa

3. Likopo tse Khahlanong le Botsofali le Bophelo bo Botle

Ha maemo a GH le IGF-1 a theoha ka tlhaho ka lilemo, CJC-1295 e ntse e tsoela pele ho ithutoa e leboitshunyako bo thibelang botsofaliho:

• Ntlafatsaboleng ba borokoletaolo ea morethetho oa circadian

• Ntlafatsaelasticity ea letlalo, ho teteana ha masapo, lemosebetsi oa ho itšireletsa mafung

• Tšehetsometabolism ea matlalekganetso ya mokgathala

4. Taolo ea Metabolic

CJC-1295 e bonts'a ts'episo ea ho buaho hanyetsa insulinle metabolic syndrome ka:

• Ntlafatsotšebeliso ea glucose

• Ho matlafatsalipid oxidationlemetabolism ea lisele tsa adipose

• Ho tshehetsataolo ya boimabathong ba batenya kapa ba nang le lefu la tsoekere

API Manufacturing le Quality Control

At Sehlopha sa Gentolex, ronaCJC-1295 APIe hlahisoa ka ho sebelisasolid-phase peptide synthesis (SPPS)le ho hloekisoa ka ho sebelisa HPLC ho finyella bohloeki bo phahameng le ho lumellana ha batch-to-batch.

Litlhaloso tsa Bohlokoa:

• Bohloeki ≥ 99%(HPLC e netefalitsoe)

• Li-solvents tse setseng tse tlase le litšepe tse boima

• Endotoxin-mahala, tsela e seng ea immunogenic synthesis

• E fumaneha kabongata ba tloaelo: milligram ho ea ho kilogram sekala

Likopo le Monyetla oa Bokamoso

CJC-1295 e nkuoa e le e 'ngoe ea li-analogue tsa GHRH tse ts'episang ka nako e telele, tse ka sebelisoang ho:

• Phekolo ea khaello ea batho ba baholo ba GH

• Taolo ea sebopeho sa 'mele ho botenya le botsofali

• Ho tsosolosoa ho tloha ho lahleheloa ke mesifa kapa ho sithabela maikutlo

• Ntlafatso ea ts'ebetso le ho hlaphoheloa maemong a kliniki kapa lipapaling

• Phekolo e tšehetsang mokhathala o sa foleng, fibromyalgia, le ho se leka-lekane ha neuroendocrine

Liteko tsa kliniki tse tsoelang pele li ntse li hlahloba tšebeliso ea eona e le mokhoa o mong oa horecombinant GH, haholo-holo bathong ba batlangho bolokehile, ho feta ho feto-fetoha ha lihomone tsa 'mele.