Cagrilintide

Cagrilintide API

Cagrilintideke ntho e sebetsang nako e telele, e entsoeng ka lik'hemik'haleamylin receptor agonist, e ntlafalitsoeng e le pheko e ncha bakeng sabotenya le mathata a amanang le boima ba 'mele. E etselitsoe ho etsisa liphello tsaamylin ea mothoHormone e kopantsoeng le insulin ke lisele tsa pancreatic β, tse bapalang karolo ea bohlokoa ho laola ho jeoa ha lijo, ho tsoa ka mpeng le ho khora.

Cagrilintide e ntse e ntlafatsoa joalo kakalafo e nang le ente hang ka beke, e fanang ka tharollo e tšepisang haholo bakeng sataolo ya boima bo sa foleng, haholo ha e sebelisoa kaHo kopana le GLP-1 receptor agonistsjoalo kaSemaglutide.

Mokhoa oa Ts'ebetso

Cagrilintide e fana ka litlamorao tsa eona tsa kalafo ka ho tlama le ho kenya tšebetsongli-receptor tsa amylin, e lebisang ho:

• Khatello ea takatso ea lijo

• Ho tsoa ka maleng ho lieha, e lelefatsang maikutlo a ho tlala

• Ho fokotseha ha khalori le ho eketseha ha satiety

Taolo ena ea multimodal ea ho ja lijo e etsa hore e be mokhethoa ea loketseng ho laolabotenya le likotsi tse amanang le cardiometabolic.

Lipatlisiso le Boitsebiso ba Clinical

Cagrilintide e bontšitse liphetho tse tšepisang litekong tse 'maloa tsa bongaka, ho kenyelletsaLithuto tsa Phase 2 tse entsoeng ke Novo Nordisk:

• Ha e sebelisoafeela, Cagrilintide e lebisa hotahlehelo ea boima ba 'mele e itšetlehileng ka tekanyo, ka ho fihlelaPhokotso ea boima ba 'mele ka 10.8%.ho feta libeke tse 26 ho batho ba batenya.

• Nenge kopantsoe le Semaglutide, phello ea ho theola boima ba 'mele e matlafatsoa haholo-ho finyellaphokotso e kgolo ya boima ba mmele hofeta moemeli a le mong.

• E bontšitsemamello e ntleleboemo bo tsitsitseng ba polokeho, 'me boholo ba liketsahalo tse bohloko ke matšoao a bobebe a mala.

Mokhoa ona oa ho kopanya ke karolo ea bohlokoa eamoloko o latelang oa lithethefatsi tse khahlanong le botenya, e shebileng litsela tse ngata tsa ho khora (amylin + GLP-1).

Boleng ba API le Tlhahiso

Tsa ronaCagrilintide API:

• E hlahiswa ka e tsoetseng pelesolid-phase peptide synthesis (SPPS)ka bohloeki bo phahameng le botsitso ba lik'hemik'hale

• E etselitsoentshetsopele ya sebopeho sa ente

• Kopana le machabalitekanyetso tsa meriana (ICH, GMP, FDA)

• E fumaneha hoteko ea tlhahiso ea khoebo, e loketseng ts'ebeliso ea bongaka le ea indasteri

Matla a Phekolo

Cagrilintide e emela amochine o mochataolong ea boima ba 'mele ho feta monotherapy ea GLP-1. Profaele ea eona ea ketso e tlatselletsang e etsa hore e tšoanelehe bakeng sa:

• Bakuli ba botenya le ba batenya haholo(ka lefu la tsoekere kapa ntle le lona)

• Phekolo ea motsoakobakeng sa ho fokotsa boima ba 'mele

• Tsoelo pele ka moso kametabolic syndrome le prediabetes