BPC-157
BPC-157 API
BPC-157 (lebitso le felletseng: Motsoako oa Tšireletso ea 'Mele 157) ke peptide e khuts'oane ea maiketsetso e entsoeng ka li-amino acid tse 15, e nkiloeng letotong la liprotheine tsa tlhaho tse sireletsang lero la motho ka mpeng. E bonts'itse matla a pharalletseng a tokiso ea linama le ho thibela ho ruruha lithutong tsa liteko mme e nkuoa ka bongata e le mokhethoa ea ts'episang haholo oa lithethefatsi tsa peptide.
Joaloka motsoako o sebetsang oa meriana (API), BPC-157 e 'nile ea sebelisoa likarolong tse ngata tsa lipatlisiso tsa saense ho pota lefatše ho hlahloba mosebetsi oa eona oa likokoana-hloko ka har'a pampiri ea mala, tsamaiso ea mesifa, tsamaiso ea methapo, tsamaiso ea pelo le ho lokisoa ha lisele tse bonolo, haholo-holo ho lokisoa ha mahlomola le lipatlisiso tse khahlanong le ho ruruha.
Mokhoa oa ho etsa lipatlisiso le oa pharmacological
BPC-157 e 'nile ea ithutoa haholo, haholo-holo litekong tsa liphoofolo tsa vivo le mefuta ea lisele tsa in vitro,' me ho fumanoe hore e na le liphello tse latelang tsa bohlokoa tsa meriana:
1. Ho tsosolosoa ha lisele le ho lokisoa ha mahlomola
E khothalletsa ho tsosolosoa ha tendon, ligament, masapo le lisele tse bonolo, 'me e ka ntlafatsa angiogenesis (angiogenesis).
Ho potlakisa pholiso ea maqeba, ho lokisoa ka mor'a ts'ebetso le ho hlaphoheloa ha likotsi tsa lisele tse bonolo, tse netefalitsoeng mefuteng ea liphoofolo tse kang ho phatloha ha tendon, ho tsieleha ha mesifa le ho robeha.
2. Tšireletso le ho lokisa mala a mala
Mehlala e kang seso sa ka mpeng, enteritis, le colitis, BPC-157 e na le ts'ireletso e kholo ea mucosal.
E ka hanela tšenyo ea mala e bakoang ke lithethefatsi tse seng khahlanong le ho ruruha (NSAIDs) le ho khothalletsa pholiso ea mala a mala.
3. Anti-inflammatory le immunomodulatory
E laola ho leka-lekana ha tsamaiso ea 'mele ea ho itšireletsa mafung ka ho thibela lintho tse thibelang ho ruruha (tse kang TNF-α, IL-6) le ho laola lintho tse khahlanong le ho ruruha.
E na le boleng bo ka bang teng e le kalafo e thusang bakeng sa mafu a sa foleng a ho ruruha joalo ka **ramatiki ea rumatoid le lefu la ho ruruha ha mala (IBD)**.
4. Neuroprotection le neuro regeneration
Mehlala ka mor'a kotsi ea lesapo la mokokotlo, ho ferekana ha methapo, le liketsahalo tsa cerebrovascular, BPC-157 e ka khothalletsa ho tsosolosoa ha methapo le ho fokotsa tšenyo ea methapo.
E ka loants'a mathata a lefapha la neuropsychiatric joalo ka ho tšoenyeha, khatello ea maikutlo le ho itšetleha ka tahi (mohato oa liteko).
5. Tšireletso ea pelo le methapo ea mali
BPC-157 e ka ntlafatsa ho kenella ha methapo ea mali le ho khothalletsa ho lokisoa ha microvascular, 'me ho lumeloa hore e na le phello e ntle ho mafu a kang myocardial ischemia, venous thrombosis le kotsi ea methapo.
Liphetho tsa lipatlisiso tsa liteko le tsa pele
Le hoja BPC-157 e e-s'o amoheloe ka ho pharaletseng bakeng sa meriana ea ngaka ea batho, e bontšitse litekong tsa liphoofolo:
Ho potlakisa ho hoholo ha nako ea ho lokisa lisele (joalo ka 50% ho potlakisa pholiso ea tendon)
Ho fokotsa haholo boemo ba ho tsoa mali ka mpeng, kotsi ea mala, le liso tsa mala
Ntlafatsa ho hlaphoheloa ha methapo ea kutlo le ho ntlafatsa ts'ebetso ea sebaka se innervated
Eketsa angiogenesis le sekhahla sa sebopeho sa lisele tsa granulation
Ka lebaka la liphetho tsena, BPC-157 e fetoha molek'hule oa bohlokoa oa ho etsa lipatlisiso mafapheng a tokiso ea kamora ho sithabela maikutlo, likotsi tsa lipapali, mafu a mala le mafu a neurodegenerative.
Tlhahiso ea API le taolo ea boleng
BPC-157 API e fanoeng ke Sehlopha sa rona sa Gentolex e amohela ts'ebetso e tiileng ea "phase synthesis" (SPPS) mme e hlahisoa tlas'a maemo a GMP. E na le litšobotsi tse latelang:
Bohloeki bo phahameng: ≥99% (ho lemoha HPLC)
Masala a litšila a tlase, ha a na endotoxin, ha a na tšilafalo ea tšepe e boima
Ho tsitsa ha sehlopha, ho pheta-pheta ho matla, ts'ebeliso ea boemo ba ente ea tšehetso
Ts'ehetso ea phepelo ea boemo ba gram le kilogram ho fihlela litlhoko tsa mekhahlelo e fapaneng ho tloha ho R&D ho isa indastering.
