Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Tšebeliso ea Lipatlisiso:
Tetrapeptide ena e sirelelitsoeng e sebelisoa ho peptide synthesis le lithuto tsa conformational. Ho kenyelletsoa ha Aib (α-aminoisobutyric acid) ho lumella bafuputsi ho etsa lipatlisiso ka sebopeho sa helical le boitšoaro ba ho mena ka li-peptide tse khutšoane. Lihlopha tse sirelelitsoeng tse sebetsang (Boc, Trt) li netefatsa botsitso le khetho nakong ea motsoako o tiileng oa peptide, e leng se etsang hore e be mohlala oa bohlokoa bakeng sa ho ithuta ka matla a mokokotlo oa peptide le ho sebelisana ka mahlakoreng.

Mosebetsi:
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH e sebetsa e le motsoako oa mohlala bakeng sa ho hlahloba botsitso ba peptide le mekhoa ea meralo. Aib e kenya letsoho ho tsitsang ha helical, ha masala a histidine le glutamine a fana ka libaka tse ka bang teng tsa ho sebelisana, tse thusang ho rala li-peptide tsa bioactive kapa ho etsisa likhechana tsa protheine. E ka boela ea e-ba selelekela sa li-peptide tse sebetsang ntlafatsong ea lithethefatsi kapa litekong tsa biochemical.