Zilebesiran

Silebesiran (API)

Tšebeliso ea Lipatlisiso:
Zilebesiran API ke lipatlisiso tse nyane tse sitisang RNA (siRNA) tse ntlafalitsoeng bakeng sa kalafo ea khatello ea mali. E lebisitse hoAGTgene, e kenyang angiotensinogen-e leng karolo ea bohlokoa ea renin-angiotensin-aldosterone system (RAAS). Lipatlisisong, Zilebesiran e sebelisetsoa ho ithuta mekhoa ea ho khutsisa liphatsa tsa lefutso bakeng sa taolo ea nako e telele ea khatello ea mali, theknoloji ea ho fana ka RNAi, le karolo e pharaletseng ea tsela ea RAAS ho mafu a pelo le a renal.

Mosebetsi:
Zilebesiran e sebetsa ka ho khutsisaAGTmRNA sebeteng, e leng se bakang ho fokotseha ha tlhahiso ea angiotensinogen. Sena se lebisa ho fokotseha ha maemo a angiotensin II, ho thusa ho theola khatello ea mali ka mokhoa o tsitsitseng. Joalo ka API, Zilebesiran e thusa ho nts'etsapele liphekolo tsa nako e telele, tsa subcutaneous antihypertensive tse nang le monyetla oa ho etsa dosing ea kotara kapa habeli, ho fana ka tlhokomelo e ntlafetseng le taolo ea khatello ea mali.