Tadalafil 171596-29-5 ho phekola ho se sebetse ha erectile ho banna

Tadalafil (Tadalafil, Tadalafil) e na le mokhoa oa molek'hule oa C22H19N3O4 le boima ba molek'hule oa 389.4. E 'nile ea sebelisoa haholo ho phekola ho se sebetse ha banna ho tloha 2003, ka lebitso la khoebo Cialis (Cialis). Ka June 2009, FDA e amohetse tadalafil United States bakeng sa phekolo ea bakuli ba nang le khatello ea kelello ea methapo ea methapo (PAH) tlas'a lebitso la khoebo Adcirca. Tadalafil e ile ea hlahisoa ka 2003 e le lithethefatsi bakeng sa phekolo ea ED. E sebetsa ka mor'a metsotso e 30 ka mor'a tsamaiso, empa phello e ntle ka ho fetisisa ke 2h ka mor'a hore ketso e qale, 'me phello e ka nka 36h,' me phello ea eona ha e amehe ke lijo. Tekanyo ea tadalafil ke 10 kapa 20 mg, tekanyo ea pele e khothalletsoang ke 10 mg, 'me tekanyo e lokisoa ho latela karabelo ea mokuli le liketso tse mpe. Liphuputso tsa pele ho maraka li bontšitse hore ka mor'a ho tsamaisoa ka molomo oa 10 kapa 20 mg ea tadalafil bakeng sa libeke tsa 12, litekanyetso tse sebetsang hantle ke 67% le 81%, ka ho latellana. Liphuputso tse ngata li bontšitse hore tadalafil e na le katleho e ntle ea phekolo ea ED.

Erectile Dysfunction: Tadalafil ke mofuta o khethiloeng oa phosphodiesterase 5 (PDE5) joaloka sildenafil, empa sebopeho sa eona se fapane le sa morao-rao, 'me lijo tse nang le mafura a mangata ha li kena-kenane le ho monya ha eona. Tlas'a ketso ea ts'usumetso ea thobalano, nitric oxide synthase (NOS) lipheletsong tsa methapo ea penile le lisele tsa vascular endothelial li etsa hore ho be le motsoako oa nitric oxide (NO) ho tloha substrate L-arginine. NO activates guanylate cyclase, e fetolang guanosine triphosphate ho cyclic guanosine monophosphate (cGMP), ka tsela eo e kenya protheine kinase e itšetlehileng ka guanosine monophosphate, e leng se bakang phokotseho ea li-ion tsa calcium liseleng tse boreleli tsa mesifa, e leng se bakang corpus cavernosum Erection e etsahala ka lebaka la ho phomola ha mesifa e boreleli. Phosphodiesterase type 5 (PDE5) e theola cGMP hore e be lihlahisoa tse sa sebetseng, ho etsa hore botona bo be boemong bo fokolang. Tadalafil e thibela ho senyeha ha PDE5, e lebisang ho bokelleng ha cGMP, e khathollang mesifa e boreleli ea corpus cavernosum, e lebisang ho penile erection. Kaha li-nitrate ha li na bafani, tšebeliso e kopantsoeng le tadalafil e tla eketsa haholo boemo ba cGMP mme e lebise ho hypotension e matla. Ka hona, ts'ebeliso e kopaneng ea tse peli e hanana le ts'ebetso ea bongaka.

Tadalafil e sebetsa ka ho thibela PDES. GMP e senyehile, kahoo tšebeliso e kopantsoeng le nitrate e ka baka ho theoha ho feteletseng ha khatello ea mali le ho eketsa kotsi ea syncope. Li-inducers tsa CY3PA4 li tla fokotsa bioavailability ea tadanafil, 'me motsoako le rifampicin, cimetidine, erythromycin, clarithromycin, itracon, ketocon, le HVI protease inhibitors li ka eketsa khatello ea mali ea moriana e lokela ho fetoloa. Ho fihlela joale, ha ho na litlaleho tsa hore litekanyetso tsa pharmacokinetic tsa sehlahisoa sena li angoa ke lijo le joala.