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Tadalafil 171596-29-5 ho phekola ho ba le lefu lena ho banna

Tlhaloso e khutšoane:

Ke Che: 171596-29-5

Foromo ea limolecular: C22h19N3O4

Boima ba moleng: 389.4

Nomoro ea EINECS: 687-7822-2

Ntlha e qhibilihang: 298-300 ° C

Khoele ea Kola: 679.1 ± 55.0 ° C (e boletsoeng esale pele)

'Mala: tšoeu ho beige

Ketsahalo ea Optical: (Opticalactivity) [α] 68To + 78 °, C = 1 ho Chloro Foromo-D

Ho tsilatsila: ho sa tsitsa ho methanol


Lintlha tsa sehlahisoa

Li-tag tsa lihlahisoa

Lintlha tsa sehlahisoa

Lebitso Tudalafil
Nomoro ea CAS 171596-29-5
Foromo ea limolecular C22h19N3O4
Boima ba Molecular 389.4
Nomoro ea Einecs 687-7822-2
Ho potoloha ka ho khetheha D20 + 71.0 °
Letsoalo 1.51 ± 0.1g / cm3 (e boletsoeng esale pele)
Boemo ba polokelo 2-8 ° C
Foromo Phofo
Acidity cormety (Pka) 16.68 ± 0.40 (a boletsoeng esale pele)
Sekhahla sa Metsi DMSO: qhibilila ea 20g / ml,

Synonyms

Tudlalafil; Cialis; IC 351; (6r, 12ar) -6 (Benzo [ea 1,3] Dioxoldropyra; gf 196960;

Phello ea pharmaColoCologana

Tadalafil (Tadalafil, Tidafil) e na le mofuta oa limolecular ea c22h19n3o4 le boima ba limolek'hule tsa 389.4. E sebelisitsoe haholo kalafong ea batho ba etsitso ea banna ho tloha 2003, le lebitso la khoebo Cialis (cialis). Ka June 2009, FDA e ile ea amohela TAADALAFIL United States bakeng sa kalafo ea bakuli ba nang le Hymory ea Matricmone ka tlasa lebitso la khoebo Adcurca. Tadalafil o ile a tsebisoa ka 2003 e le sethethefatsi bakeng sa kalafo ea Ed. E boetse e etsa metsotso e 30 ka mor'a tsamaiso, empa phello ea eona e ntle ke 2h kamora ho qala ho qala, 'me phello ea eona ha e angoe ke lijo. Tekanyetso ea Tadalafil e 10 kapa 20, tekanyetso e khothalletsoang ea pele ke 10 mg, mme tekanyetso e fetotsoe ho latela karabelo ea mokuli le karabelo e mpe. Boithuto ba 'marakeng pele li bontšitse hore kamora tsamaiso ea molomo oa 10 kapa 20 ea TADAFIL bakeng sa libeke tse 12, litefiso tse sebetsang li 67% le 81%, ka ho latellana. Boithuto bo bongata bo bontšitse hore Tadalafil e sebetsa hantle haholo kalafong ea Ed.

 

E harela Dysfunction: Tadalafil ke sesebelisoa se ikhethileng sa 5 (PDe5) joalo ka sawenentera " Tlas'a ketso ea ho kopanela liphate, nitric oxtase (nos) Ha ho na ts'ebetso ea grayanyante cyclase, e fetolang Guanosinesphate ea stinasosphate (cymp Pradio Short 5 (PDe5) Degrade Lihlahisoa Lihlahisoa Lihlahisoa tsa Batsoali, Ho Etsa Pisino Sebetsa Naha e Mekeleng. Tadalafil o thibela pherekano ea PDE5, e lebisang pokello ea CGP, e ratang mesifa e boreleli ea cavernosum ea Corpus, e lebisang ho pente. Kaha li-nitrate ha li na batho ba fanang ka tsona, tšebeliso e kopaneng le tudalafil e tla eketsa boemo ba cgmp le ho lebisa ho hypote e matla. Ka hona, tšebeliso e kopaneng ea tse peli e hokahasoa ka mokhoa oa bongaka.

 

Tadalafil o sebetsa ka ho thibela li-pdes. GMP e senyehile, kahoo ts'ebeliso e kopaneng le nitrate e ka baka ho theoha ha khatello ea mali ebe e eketsa kotsi ea Syncope. Cy3pa4 musihlars e tla fokotsa setlhare sa tadanafil, cimthromycin, ITTrackin, ITTRACINCIN, Ery Ho fihlela hajoale, ha ho na litlaleho tsa hore Phatlalatso ea PharmaCkikikiet ea sehlahisoa sena e angoa ke lijo le joala.


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