Semaglutide
Semaglutide API
Semaglutide ke synthetic glucagon-like peptide-1 (GLP-1) receptor agonist e entsoeng ka nako e telele, e etselitsoeng ho phekola lefu la tsoekere la mofuta oa 2 le botenya. E fetotsoe ka mokhoa oa ho hanela ho senyeha ha enzymatic le ho ntlafatsa halofo ea bophelo, Semaglutide e lumella hore ho be le dosing e bonolo hanngoe ka beke, ho ntlafatsa haholo ho khomarela mokuli.
Tsa ronaSemaglutide APIe hlahisoa ka mokhoa oa maiketsetso ka botlalo, e felisang likotsi tse amanang le lits'ebetso tsa tlhaho tsa tlhaho, joalo ka protheine ea lisele tse amohelang kapa tšilafalo ea DNA. Ts'ebetso eohle ea tlhahiso e se e ntlafalitsoe le ho netefatsoa ka tekanyo ea kilogram, ho fihlela litlhoko tse thata tse boletsoeng ho tataiso ea FDA ea 2021 mabapi le tlhahiso ea ANDA bakeng sa litlhare tsa maiketsetso tsa peptide tse hloekileng haholo.
Mokhoa oa Ts'ebetso
Semaglutide e etsisa GLP-1 ea motho, hormone ea incretin e bapalang karolo ea bohlokoa ho metabolism ea tsoekere. E sebetsa ka mekhoa e mengata ea synergistic:
-
E matlafatsa tlhahiso ea insulinka mokhoa o itšetlehileng ka glucose
-
E thibela tlhahiso ea glucagone fokotsa tlhahiso ea tsoekere ea sebete
-
E lieha ho tsoa ka mpeng, e lebisang ho ntlafatseng taolo ea glycemic ea postprandial
-
E fokotsa takatso ea lijo le ho noa matla, ho tšehetsa tahlehelo ea boima ba 'mele
Liphello tsa Tleliniki
Lithuto tse ngata tsa kliniki (mohlala, liteko tsa SUSTAIN le STEP) li bontšitse hore Semaglutide:
-
E theola haholo HbA1c le boemo ba tsoekere ea plasma e potlakileng ho bakuli ba lefu la tsoekere la mofuta oa 2
-
E khothaletsa ho theola boima ba 'mele ho batho ba batenya kapa ba batenya haholo
-
E fokotsa matšoao a kotsi a pelo joalo ka khatello ea mali le ho ruruha
Ka profil e ntle ea polokeho le melemo e pharalletseng ea metabolic, Semaglutide e fetohile GLP-1 RA ea pele ho lefu la tsoekere le kalafo e khahlanong le botenya. Phetolelo ea rona ea API e boloka botšepehi bo phahameng ba sebopeho le maemo a tlaase a litšila (≤0.1% litšila tse sa tsejoeng ke HPLC), ho netefatsa hore ho na le ts'ebetso e ntle ea phekolo ea meriana.
