REVERSE T3 bakeng sa protheine synthesis, thermoregulation, tlhahiso ea matla le taolo
Lintlha tsa Sehlahisoa
| Lebitso | RETS'ELISITSOE T3 |
| Nomoro ea CAS | 5817-39-0 |
| Mokhoa oa limolek'hule | C15H12I3NO4 |
| Boima ba molek'hule | 650.97 |
| Sebaka se qhibilihang | 234-238°C |
| Ntho e belang | 534.6±50.0°C |
| Bohloeki | 98% |
| Polokelo | Boloka sebakeng se lefifi, se koetsoe moo ho omileng, Boloka ka sehatsetsing, ka tlas'a -20°C |
| Sebopeho | Phofo |
| Mmala | Pale Beige ho Brown |
| Ho paka | PE mokotla + Aluminium mokotla |
Litlhaloso tse tšoanang
ReverseT3(3,3',5'-Triiodo-L-Thyronine);L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-;(2S) -2-aMino-3-[4-(4-hydroxy-3,5-diiodophe) noxy) -3-iodophenyl]propanoicacid;REVERSET3;T3;LIOTHYRONIN;L-3,3',5'-TRIIODOTHYRONINE;3,3′,5′-Triiodo-L-thyronine(ReverseT3)tharollo
Phello ea Pharmacological
Tlhaloso
Thyroid gland ke tšoelesa e kholo ka ho fetisisa ea endocrine 'meleng oa motho,' me lintho tse ka sehloohong tse sebetsang tse patiloeng ke tetraiodothyronine (T4) le triiodothyronine (T3), tse bohlokoa haholo bakeng sa motsoako oa protheine, taolo ea mocheso oa 'mele, tlhahiso ea matla le karolo ea taolo. Bongata ba T3 e serum e fetoloa ho tloha ho peripheral tissue deiodination, 'me karolo e nyenyane ea T3 e patoa ka ho toba ke qoqotho ebe e lokolloa maling. Boholo ba T3 e serum e tlamahane le liprotheine tse tlamang, hoo e ka bang 90% ea eona e tlamahane le thyroxine-binding globulin (TBG), e setseng e tlameletsoe ho albumin, 'me chelete e nyenyane haholo e tlameletsoe ho thyroxine-binding prealbumin (TBPA). Litaba tsa T3 ka serum ke 1/80-1/50 ea T4, empa ts'ebetso ea bioloji ea T3 ke makhetlo a 5-10 a T4. T3 e bapala karolo ea bohlokoa ho ahlolang boemo ba 'mele oa motho, kahoo ho bohlokoa haholo ho lemoha litaba tsa T3 serum.
Bohlokoa ba Clinical
Boikemisetso ba triiodothyronine ke e 'ngoe ea matšoao a hlokolosi bakeng sa tlhahlobo ea hyperthyroidism. Ha hyperthyroidism e eketseha, e boetse e le selelekela sa ho khutla ha hyperthyroidism. Ho phaella moo, e tla boela e eketsehe nakong ea bokhachane le lefu la sebete le matla. Hypothyroidism, goiter e bonolo, nephritis e matla le e sa foleng, lefu la sebete le sa foleng, sebete sa sebete se fokotsehile. Serum T3 concentration e bonahatsa mosebetsi oa tšoelesa ea qoqotho ka har'a lisele tse potolohileng ho e-na le boemo ba sephiri ba qoqotho. Boikemisetso ba T3 bo ka sebelisoa bakeng sa tlhahlobo ea T3-hyperthyroidism, ho tsebahatsa hyperthyroidism ea pele le tlhahlobo ea pseudothyrotoxicosis. Kakaretso ea serum ea T3 ka kakaretso e lumellana le phetoho ea boemo ba T4. Ke sesupo se hlokolosi bakeng sa tlhahlobo ea ts'ebetso ea qoqotho, haholo-holo bakeng sa tlhahlobo ea pele. Ke sesupo se ikhethileng sa tlhahlobo ea T3 hyperthyroidism, empa ha e na boleng bo fokolang bakeng sa tlhahlobo ea ts'ebetso ea qoqotho. Bakeng sa bakuli ba tšoaroang ka lithethefatsi tsa qoqotho, e lokela ho kopanngoa le kakaretso ea thyroxine (TT4) 'me, haeba ho hlokahala, thyrotropin (TSH) ka nako e le 'ngoe ho thusa ho ahlola boemo ba mosebetsi oa qoqotho.
