Rapamycin ke lithethefatsi tse ikemetseng, anti-kankere le setšoantšo sa anti-anti-khaled

Rapamycin ke lithethefatsi tse nang le terompeta, anti-kankere le anti-botsofali

Tlhaloso e khutšoane:

Ntlha ea ho qhibiliha: 183-185 ° C

Kopo ea Phello: 799.83 ° C: (Khakanyo e mpe)

Ho potoloha ka tsela e itseng: D25-58.2 ° (methanol)

Bongata: 1.0352 (Khakanyo e mpe)

Polelo ea Flash: 87 ° C

Maemo a polokelo: -20 ° C'l c

Foromo: Powder

Acidity cormeity: (pka) 10.40 ± 0.70 (e boletsoeng esale pele)

'Mala: tšoeu ho mosehla

Scoubity ea Metsi: E inkela metsi

Sensitivity: Mongobo o se nang kelello / o bobebe / hygroscopic

Romella lengolo-tsoibila ho rona

Lintlha tsa sehlahisoa

Li-tag tsa lihlahisoa

Lintlha tsa sehlahisoa

Lebitso	Rapamycin
Nomoro ea CAS	53123-88-9
Foromo ea limolecular	C51h79N913
Boima ba Molecular	914.19
Nomoro ea Einecs	610-965-5-5
Poleft Point	799.83 ° C (e boletsoeng esale pele)
Letsoalo	1.0352
Boemo ba polokelo	E tiisitsoeng ka ho omella, e boloketsoe Mahala a lazerzer, ka tlase ho Cels -20 ° C
Foromo	Phofo
Mmala	Tšoeu
Packing	Pla ea mokotla + aluminium Bag

Synonyms

AY 22989; 23,27-epoxy-3H-Pyrido (2,1-C) (1,1-C) (1,1-C) (1,1-C) (1,1-22) Rapamune; Rapamyckin Hygroscokus; RPM

Phello ea pharmaColoCologana

Tlhaloso

Rapamycin ke moriana o thibelang macrolibetic o ts'oanang le procofol (FK506), empa e na le mochini o fapaneng oa ho ameha haholo oa ho ameha haholo. FK506 e sitisa ho fetoloa ha T Lymphoctes ho tloha G1 mohato oa G1 ho ea ho tsoa ho F1CHOCE E TSOANG PELENG LE FASCAMES. Univesithi ea Chicago ea Chicago e sebelisa matlapa a ho fumaneha ka khoebo le lefu la marang-rang le Europe, ka ho etsa joalo a pholoha pholohe ea bakuli. Boithuto bo bontšitse hore rapamycin e bolaoa habonolo ke enzyme ea lijo, le lero le ka thibelang mafu a ho senya lijo ho rapamycin. E ka ntlafatsa bioavalility ea rapalycin. Ho thoe lingaka tsa maDutch tsa pele tsa ma-Dutch li fumane hore lero la morara le fumaneletse ho ntlafa hoa ho ntlafatsoa ha molomo, hape ho na le lingaka tse linaheng tsa Europe tsa Purceycin.

Lilemong tsa morao tjena, lithuto li fumane hore ho na le koetliso ea rapamycin (mtor) ke ho ba ho se tsotelle tsela ea hae ea ho etsa joalo ho ka susumetsa mafu a fapaneng. Joaloka mohloekisi ea shebiloeng oa WOR, Rafamycin e ka tšoara masholu ana, kankere ea makoala, kankere ea matsoele, neuroendocrine. Haholo-holo kalafong ea mafu a mabeli a rare, lam (lymphangmyyomatosis), phello e ntle le ho feta, lam le TSC le eona e ka nkuoa e le mafu a hlatsoang hlako.

Litlamorao

Rapamycin (RaPA) e na le litlamorao tse tšoanang ho FK506. Ka palo e kholo ea litekanyo tsa tlhaho, litlamorao tsa eona li ile tsa fumaneha hore li itšetleha ebile li fetohe, 'me litlamorao tsa bona li sa fumanoa li ba le li-nepper ha li na le hyperplies. Litla-kholo tse kholo le tse nang le mahlakore a kenyelletsa: hlooho, ho nyekeloa ke pelo, ho nyekeloa ke pelo, ho tebela, ho na le bohloko. Litšila tsa laboratori li kenyeletsa: thrombocystopenia, Hyperfelemia, Hyporfmemia Haufinyane ho tlalehiloe ka molao-motheo oa Rapa, 'me ho nahanoa hore maemo a mocheso a tlase a plasma a tlase ho phosphate e fetisitsoeng ke kalafo e thehiloeng ho impurages. Joalo ka li-izisupeta tse ling tsa itšilafatsa, rapa e na le monyetla o moholo oa ts'oaetso, ka tloaelo e tlalehiloeng ea tšoaetso ea pneumonia haholo le CSA.

E fetileng: Ru-58841 e sebelisitsoeng e le thibelo ea ho lahleheloa ke moriri le lefapha la banna

E 'ngoe: Chondroitin sulfate ea kalafo ea lefu la pelo ea pelo, ramatiki le pholiso ea mapolanka a Corneal 98%

Ngola molaetsa oa hau mona 'me u e romelle ho rona