Lihlahisoa
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Givosiran
Givosiran API ke RNA e nyane e sitisang e nyane (siRNA) e ithutoang bakeng sa kalafo ea acute hepatic porphyria (AHP). E shebane ka ho khetheha leALAS1gene (aminolevulinic acid synthase 1), e amehang tseleng ea heme biosynthesis. Bafuputsi ba sebelisa Givosiran ho batlisisa mekhoa ea phekolo e thehiloeng ho RNA (RNAi), ho khutsisa liphatsa tsa lefutso tse lebisitsoeng ho sebete, le ho feto-fetoha ha mekhoa ea metabolic e amehang ho porphyria le mathata a amanang le lefutso.
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Pegcetacoplan
Pegcetacoplan ke pegylated cyclic peptide e sebetsang e le sepheo sa C3 complement inhibitor, e entsoeng bakeng sa phekolo ea mafu a tlatselletsang a kang paroxysmal nocturnal hemoglobinuria (PNH) le geographic atrophy (GA) ho senyeha ha macular ho amanang le lilemo.
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Plozasiran
Plozasiran API ke RNA e nyane e sitisang e nyane (siRNA) e ntlafalitsoeng bakeng sa kalafo ea hypertriglyceridemia le mathata a amanang le pelo le metabolic. E lebisitse hoAPOC3gene, e kenyelletsang apolipoprotein C-III, e laolang metabolism ea triglyceride. Lipatlisisong, Plozasiran e sebelisetsoa ho ithuta maqheka a theolang lipid a thehiloeng ho RNAi, ho khetholla liphatsa tsa lefutso, le phekolo ea nako e telele bakeng sa maemo a kang malapa a chylomicronemia syndrome (FCS) le dyslipidemia e tsoakiloeng.
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Zilebesiran
Zilebesiran API ke lipatlisiso tse nyane tse sitisang RNA (siRNA) tse ntlafalitsoeng bakeng sa kalafo ea khatello ea mali. E lebisitse hoAGTgene, e kenyang angiotensinogen-e leng karolo ea bohlokoa ea renin-angiotensin-aldosterone system (RAAS). Lipatlisisong, Zilebesiran e sebelisetsoa ho ithuta mekhoa ea ho khutsisa liphatsa tsa lefutso bakeng sa taolo ea nako e telele ea khatello ea mali, theknoloji ea ho fana ka RNAi, le karolo e pharaletseng ea tsela ea RAAS ho mafu a pelo le a renal.
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Palopegteriparatide
Palopegteriparatide ke parathyroid hormone receptor agonist ea nako e telele (PTH1R agonist), e entsoeng bakeng sa phekolo ea hypoparathyroidism e sa foleng. Ke analog ea pegylated ea PTH (1-34) e etselitsoeng ho fana ka taolo e tsitsitseng ea calcium ka dosing hang ka beke.
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GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide-6) ke hexapeptide ea maiketsetso e sebetsang e le secretagogue ea kholo ea hormone, e susumetsang tokollo ea tlhaho ea 'mele ea ho hōla ha hormone (GH) ka ho kenya receptor ea GHSR-1a.
Likarolo tsa API :
Bohloeki ≥99%
E entsoe ka solid-phase peptide synthesis (SPPS)
E fanoe bakeng sa R&D le tšebeliso ea khoebo
GHRP-6 ke peptide ea lipatlisiso e feto-fetohang bakeng sa ts'ehetso ea metabolism, tsosoloso ea mesifa, le ho feto-fetoha ha li-hormone.
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GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) ke hexapeptide ea maiketsetso le li-hormone tsa ho hōla tse matla secretagogue, e etselitsoeng ho susumetsa tlhahiso ea tlhaho ea hormone ea ho hōla (GH) ka ho kenya receptor ea GHSR-1a hypothalamus le pituitary.
Likarolo tsa API:
Bohloeki ≥99%
E fumaneha bakeng sa R&D le phepelo ea khoebo, e nang le litokomane tse felletseng tsa QC
GHRP-2 ke peptide ea bohlokoa ea lipatlisiso mafapheng a endocrinology, meriana e nchafatsang, le liphekolo tse amanang le lilemo.
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Hexarelin
Hexarelin ke synthetic hormone secretagogue peptide (GHS) le agonist e matla ea GHSR-1a, e ntlafalitsoeng ho susumetsa ho lokolloa ha hormone e sa feleng (GH). Ke ea lelapa la ghrelin mimetic mme e entsoe ka li-amino acid tse tšeletseng (hexapeptide), e fanang ka botsitso bo ntlafetseng ba metabolism le liphello tse matla tsa ho lokolla GH ha li bapisoa le li-analogue tsa pejana tse kang GHRP-6.
Likarolo tsa API :
Bohloeki ≥ 99%
E hlahisoa ka solid-phase peptide synthesis (SPPS)
Litekanyetso tse kang GMP, endotoxin e tlase le masala a solvent
Phepelo e feto-fetohang: R&D ho isa tekanyong ea khoebo
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Melanotan II
Likarolo tsa API:
Bohloeki bo phahameng ≥ 99%
E entsoe ka solid-phase peptide synthesis (SPPS)
Endotoxin e tlase, li-solvents tse setseng tse tlase
E fumaneha ka R&D ho isa boemong ba khoebo -
Melanotan 1
Melanotan 1 API e hlahisoa ho sebelisoa theknoloji e tiileng ea "peptide synthesis" (SPPS) tlas'a maemo a thata a taolo ea boleng ba GMP.
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Bohloeki bo phahameng ≥99%
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Solid-phase peptide synthesis (SPPS)
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Litekanyetso tsa tlhahiso tse kang GMP
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Litokomane tse feletseng: COA, MSDS, data ea botsitso
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Phepelo e ka fokotsoang: R&D ho isa maemong a khoebo
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MOTS-C
MOTS-C API e hlahisoa tlas'a maemo a thata a kang a GMP ho sebelisoa theknoloji e tiileng ea "peptide synthesis" (SPPS) ho netefatsa boleng ba eona bo phahameng, bohloeki bo phahameng le botsitso bo phahameng bakeng sa lipatlisiso le tšebeliso ea phekolo.
Likarolo tsa Sehlahisoa:Bohloeki ≥ 99% (e tiisitsoe ke HPLC le LC-MS),
Endotoxin e tlase le lintho tse setseng tsa solvent,
E hlahisitsoe ho latela liprothokholo tsa ICH Q7 le GMP,
E ka fihlela tlhahiso e kholo, ho tloha ho li-batch tsa R&D tsa boemo ba milligram ho isa phepelong ea khoebo ea boemo ba gram le kilogram. -
Ipamorelin
Ipamorelin API e lokiselitsoe ka mokhoa o phahameng oa ** solid phase peptide synthesis process (SPPS) ** mme e etsa tlhahlobo e tiileng le tlhahlobo ea boleng, e loketseng tšebeliso ea pele ea liphaephe lipatlisisong tsa saense le nts'etsopele le lik'hamphani tsa meriana.
Likarolo tsa sehlahisoa li kenyelletsa:
Bohloeki ≥99% (tlhahlobo ea HPLC)
Ha ho na endotoxin, solvent e tlase e setseng, tšilafalo ea tšepe e tlase
Fana ka sete e feletseng ea litokomane tsa boleng: COA, tlaleho ea boithuto ba botsitso, tlhahlobo ea mahlaseli a litšila, joalo-joalo.
Phepelo ea boemo ba gram ~ kilogram-level