Lihlahisoa
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU ke molek'hule ea maiketsetso ea lipidated linker e etselitsoeng phano ea lithethefatsi le li-antibody-drug conjugates (ADCs). E na le mohatla oa stearoyl (Ste) hydrophobic, γ-glutamyl targeting motif, AEEA spacers bakeng sa ho feto-fetoha ha maemo, le sehlopha sa OSu (NHS ester) bakeng sa ho kopanya hantle.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH ke mohaho oa maiketsetso o sirelelitsoeng oa tripeptide o nang le leucine ea α-methylated, e atisang ho sebelisoa ho moralo oa lithethefatsi tsa peptide ho matlafatsa botsitso ba metabolism le khetho ea ho amohela.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) ke sesepa sa maiketsetso sa zwitterionic se sebelisoang haholo lipatlisisong tsa protheine ea membrane le biology ea meralo, haholo ho spectroscopy ea NMR le crystallography.
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N-Acetylneuraminic Acid(Neu5Ac Sialic Acid)
N-Acetylneuraminic Acid (Neu5Ac), eo hangata e tsejoang e le sialic acid, ke monosaccharide ea tlhaho e amehang mesebetsing ea bohlokoa ea lisele le 'mele ea ho itšireletsa mafung. E bapala karolo ea bohlokoa ho bonts'a lisele, ts'ireletso ea pathogen, le nts'etsopele ea boko.
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Ergothioneine
Ergothioneine ke tlhaho ea tlhaho ea amino acid e nkiloeng ho antioxidant, e ithutoang bakeng sa thepa ea eona e matla ea cytoprotective le e thibelang botsofali. E entsoe ke li-fungus le libaktheria 'me e bokellana ka har'a lisele tse pepesehileng khatellong ea oxidative.
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NMN
Boithuto ba pele le ba pele ba batho bo fana ka maikutlo a hore NMN e ka khothaletsa bophelo bo bolelele, mamello ea 'mele le ts'ebetso ea kelello.
Likarolo tsa API:
Bohloeki bo phahameng ≥99%
Pharmaceutical-grade, e loketseng ho etsoa ka molomo kapa ka ente
E entsoe tlas'a maemo a kang a GMP
NMN API e loketse ho sebelisoa litlhare tse thibelang botsofali, liphekolo tsa metabolism, le lipatlisiso tsa bophelo bo bolelele.
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Glucagon
Glucagon ke hormone ea tlhaho ea peptide e sebelisoang e le kalafo ea tšohanyetso bakeng sa hypoglycemia e matla mme e ithutoa ka karolo ea eona taolong ea metabolic, ho theola boima ba 'mele le tlhahlobo ea tšilo ea lijo.
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Motixafortide
Motixafortide ke peptide ea mohanyetsi oa CXCR4 e entsoeng ho bokella lisele tsa stem tsa hematopoietic (HSCs) bakeng sa phetisetso ea autologous mme e ntse e ithutoa ho oncology le immunotherapy.
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Glepaglutide
Glepaglutide ke analoge ea nako e telele ea GLP-2 e etselitsoeng kalafo ea lefu la bowel syndrome (SBS). E matlafatsa ho monya le ho hōla ha mala, ho thusa bakuli ho fokotsa ho itšetleha ka phepo ea batsoali.
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Elamipretide
Elamipretide ke tetrapeptide e lebisitsoeng ho mitochondria e etselitsoeng ho phekola mafu a bakoang ke ho se sebetse ha mitochondrial, ho kenyelletsa le myopathy ea mantlha ea mitochondrial, lefu la Barth, le ho hloleha ha pelo.
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Donidalorsen
Donidalorsen API ke antisense oligonucleotide (ASO) e ntseng e etsoa lipatlisiso bakeng sa phekolo ea angioedema ea lefutso (HAE) le maemo a amanang le ho ruruha. E ithutoa moelelong oa liphekolo tse lebisitsoeng ho RNA, ka sepheo sa ho fokotsa polelo eaplasma prekallikrein(KLKB1 mRNA). Bafuputsi ba sebelisa Donidalorsen ho hlahloba mekhoa ea ho khutsisa liphatsa tsa lefutso, pharmacokinetics e itšetlehileng ka tekanyo, le taolo ea nako e telele ea ho ruruha ha bradykinin.
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"Fitusiran"
Fitusiran API ke RNA e nyane e sitisang e nyane (siRNA) e batlisisitsoeng haholo-holo lebaleng la mathata a haemophilia le a coagulation. E lebisitse hoantithrombin (AT kapa SEPINC1)liphatsa tsa lefutso sebeteng ho fokotsa tlhahiso ea antithrombin. Bafuputsi ba sebelisa Fitusiran ho hlahloba mekhoa ea ho kena-kenana le RNA (RNAi), ho khutsisa liphatsa tsa lefutso ka sebete, le mekhoa e mecha ea phekolo ea ho leka-lekanya coagulation ho bakuli ba hemophilia A le B, ba nang le li-inhibitors kapa ba se na tsona.