Plozasiran

Plozasiran (API)

Tšebeliso ea Lipatlisiso:
Plozasiran API ke RNA e nyane e sitisang e nyane (siRNA) e ntlafalitsoeng bakeng sa kalafo ea hypertriglyceridemia le mathata a amanang le pelo le metabolic. E lebisitse hoAPOC3gene, e kenyelletsang apolipoprotein C-III, e laolang metabolism ea triglyceride. Lipatlisisong, Plozasiran e sebelisetsoa ho ithuta maqheka a theolang lipid a thehiloeng ho RNAi, ho khetholla liphatsa tsa lefutso, le phekolo ea nako e telele bakeng sa maemo a kang malapa a chylomicronemia syndrome (FCS) le dyslipidemia e tsoakiloeng.

Mosebetsi:
Plozasiran e sebetsa ka ho khutsisaAPOC3mRNA sebeteng, e lebisang phokotsong ea maemo a apolipoprotein C-III. Sena se khothalletsa ho ntlafala ha lipolysis le ho tlosoa ha lipoprotein tse ruileng tsa triglyceride maling. Joalo ka API, Plozasiran e thusa ho nts'etsapele liphekolo tsa nako e telele tse reretsoeng ho theola maemo a triglyceride haholo le ho fokotsa kotsi ea pancreatitis le liketsahalo tsa pelo ho bakuli ba nang le mathata a matla kapa a lefutso la lipid.