Orlistat 96829-58-2 Ho fokotsa ho kenngoa ha mafura a sietary, ho fella ka ho lahleheloa ke boima ba 'mele.
Lintlha tsa Sehlahisoa
| Lebitso | Orlistat |
| Nomoro ea CAS | 96829-58-2 |
| Mokhoa oa limolek'hule | C29H53NO5 |
| Boima ba molek'hule | 495.73 |
| Nomoro ea EINECS | 639-755-1 |
| Melting Point | <50°C |
| Botenya | 0.976±0.06g/cm3(E boletsoeng esale pele) |
| Boemo ba polokelo | 2-8°C |
| Sebopeho | Phofo |
| Mmala | Bosoeu |
| Acidity coefficient | (pKa) 14.59±0.23 (E boletsoeng esale pele) |
Litlhaloso tse tšoanang
(S) -2-FORMYLAMINO-4-METHYL-PENTANOICACID(S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYLESTER;RO-18-0647;(-)-TETRAHYDROLIPSTAN; ORMYL-L-LEUCINE(1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYLESTER;Orlistat(synthetase/compound);Orlistat(synthesis);Orlistat(FerMentation)
Phello ea Pharmacological
Thepa
Phofo e tšoeu ea kristale, e batlang e sa qhibilihe ka metsing, e qhibiliha habonolo ka chloroform, e qhibiliha haholo ka methanol le ethanol, e bonolo ho pyrolyze, ntlha e qhibilihang ke 40℃～42 ℃. Molek'hule ea eona ke diastereomer e nang le litsi tse 'ne tsa chiral, ka bolelele ba 529nm, tharollo ea eona ea ethanol e na le rotation e mpe ea optical.
Mokhoa oa Ts'ebetso
Orlistat ke nako e telele le e matla e khethehileng ea lipase inhibitor, e thibelang li-enzyme tse peli tse ka holimo ka ho theha maqhama a covalent le sebaka se sebetsang sa serine sa lipase ka mpeng le mala a manyenyane. Li-enzyme tse sa sebetseng li ke ke tsa senya mafura lijong hore e be mafura a mafura a mahala le Chemicalbook glycerol e ka kenngoa ke 'mele, kahoo e fokotsa ho kenngoa ha mafura le ho fokotsa boima ba' mele. Ho feta moo, liphuputso tse ling li fumane hore orlistat e thibela ho kenngoa ha k'holeseterole ka mpeng ka ho thibela niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).
Lipontšo
Sehlahisoa sena hammoho le lijo tse fokolang tsa hypocaloric li bontšoa bakeng sa phekolo ea nako e telele ea batho ba batenya le ba batenya, ho kenyelletsa le ba nang le mabaka a kotsi a amanang le botenya. Sehlahisoa sena se na le taolo ea nako e telele ea boima ba 'mele (ho theola boima ba' mele, ho boloka boima ba 'mele le ho thibela ho khutlela morao) katleho. Ho nka orlistat ho ka fokotsa maemo a kotsi a amanang le botenya le mafu a mang a amanang le botenya, ho kenyelletsa hypercholesterolemia, lefu la tsoekere la mofuta oa 2, ho se mamelle tsoekere ea mali, hyperinsulinemia, khatello ea mali, le mafura a fokotseng litho tsa 'mele.
Litšebelisano tsa Meriana
E ka fokotsa ho kenngoa ha livithamine A, D le E. E ka tlatsetsoa ka sehlahisoa sena ka nako e le 'ngoe. Haeba u nka litokisetso tse nang le livithamine A, D le E (tse kang li-multivitamine tse ling), u lokela ho nka sehlahisoa sena lihora tse 2 ka mor'a ho nka sehlahisoa sena kapa pele u robala. Batho ba nang le lefu la tsoekere la mofuta oa 2 ba ka hloka ho fokotsa tekanyetso ea lithethefatsi tsa hypoglycemic (mohlala, sulfonylureas). Tšebeliso e kopanetsoeng le cyclosporine e ka fella ka ho fokotseha ha khatello ea mali ho plasma ea morao-rao. Tšebeliso e tšoanang ea amiodarone e ka fokotsa ho monya ha eona le ho fokotsa ts'ebetso ea eona.
![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)