Retatrutide ke agonist e hlahang ea li-multi-receptor, haholo-holo e sebelisetsoang ho phekola botenya le mafu a metabolism. Ka nako e ts'oanang e ka kenya tšebetsong li-receptor tse tharo tsa incretin, ho kenyelletsa GLP-1 (glucagon-like peptide-1), GIP (insulinotropic polypeptide e itšetlehileng ka tsoekere) le glucagon receptor. Mokhoa ona o mongata o etsa hore retatrutide e bonts'e bokhoni bo boholo taolong ea boima ba 'mele, taolo ea tsoekere ea mali le bophelo bo botle ba metabolic.
Likarolo tsa mantlha le litlamorao tsa retatrutide:
1. Mekhoa e mengata ea ts'ebetso:
(1) GLP-1 receptor agonism: Retatrutide e khothalletsa secretion ea insulin mme e thibela ho lokolloa ha glucagon ka ho kenya li-receptor tsa GLP-1, ka hona e thusa ho theola tsoekere ea mali, ho lieha ho tsoa ka mpeng le ho fokotsa takatso ea lijo.
(2) GIP receptor agonism: GIP receptor agonism e ka ntlafatsa secretion ea insulin le ho thusa ho fokotsa tsoekere ea mali.
2. Glucagon receptor agonism: Glucagon receptor agonism e ka khothalletsa ho bola ha mafura le metabolism ea matla, kahoo e thusa ho theola boima ba 'mele.
3. Phello e kholo ea ho lahleheloa ke boima ba 'mele: Retaglutide e bontšitse liphello tse kholo tsa ho lahleheloa ke boima ba' mele lithutong tsa meriana 'me e loketse haholo-holo ho bakuli ba batenya kapa bakuli ba nang le lefu la metabolism. Ka lebaka la mekhoa e mengata ea ts'ebetso, e na le ts'ebetso e ikhethang ea ho fokotsa mafura a 'mele le ho laola boima ba' mele.
4. Taolo ea tsoekere ea mali: Retaglutide e ka theola tsoekere ea mali ka mokhoa o atlehileng mme e loketse haholo bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba hlokang taolo ea tsoekere ea mali. E ka thusa ho ntlafatsa kutloisiso ea insulin le ho fokotsa ho fetoha ha tsoekere ea mali ka mor'a ho ja.
5. Monyetla oa bophelo bo botle ba pelo: Leha retaglutide e ntse e le sethaleng sa lipatlisiso tsa bongaka, lintlha tsa pele li bonts'a hore e kanna ea ba le monyetla oa ho fokotsa kotsi ea liketsahalo tsa pelo le methapo, joalo ka ts'ireletso ea pelo ea litlhare tse ling tsa GLP-1.
6. Tsamaiso ea ente: Hona joale Retaglutide e tsamaisoa ka ente e ka tlaase, hangata e le mokhoa oa nako e telele hanngoe ka beke, 'me sena sa maqhubu a dosing se thusa ho ntlafatsa ho latela mokuli.
7. Litla-morao: Litla-morao tse tloaelehileng li kenyelletsa matšoao a ka mpeng a kang ho nyekeloa ke pelo, ho hlatsa le letšollo, tse tšoanang le litlamorao tsa lithethefatsi tse ling tsa GLP-1. Matšoao ana a tloaelehile haholo mehatong ea pele ea phekolo, empa hangata bakuli ba ikamahanya le maemo ha nako ea phekolo e ntse e eketseha.
Patlisiso ea bongaka le ts'ebeliso:
Retaglutide e ntse e etsa liteko tse kholo tsa bongaka, haholoholo ho lekola litlamorao tsa eona tsa nako e telele le polokeho kalafong ea botenya. Liphetho tsa liteko tsa pele tsa bongaka li bontša hore moriana o na le phello e kholo ho theoheng ha boima ba 'mele le ho ntlafatsa bophelo bo botle ba metabolism, haholo-holo ho bakuli ba nang le litlamorao tse fokolang tsa lithethefatsi tsa setso.
Retaglutide e nkuoa e le mofuta o mocha oa lithethefatsi tsa peptide tse nang le bokhoni bo boholo ba ts'ebeliso kalafong ea botenya, metabolic syndrome le mofuta oa 2 lefu la tsoekere. Ha ho phatlalatsoa lintlha tse ling tsa liteko tsa bongaka nakong e tlang, ho lebelletsoe hore e be setlhare se seng sa katleho bakeng sa kalafo ea botenya le mafu a metabolism.
Nako ea poso: May-27-2025