NAD⁺ (Nicotinamide Adenine Dinucleotide) ke coenzyme ea bohlokoa e teng liseleng tsohle tse phelang, tseo hangata li bitsoang "molek'hule ea mantlha ea matla a cellular." E sebetsa ka likarolo tse ngata 'meleng oa motho, e sebetsa e le mokhanni oa matla, mohlokomeli oa botsitso ba liphatsa tsa lefutso, le mosireletsi oa ts'ebetso ea cellular, e leng se etsang hore e be sa bohlokoa bakeng sa ho boloka bophelo bo botle le ho lieha ho tsofala.
Ho metabolism ea matla, NAD⁺ e thusa ho fetolela lijo hore e be matla a ka sebelisoang. Ha lik'habohaedreite, mafura le liprotheine li robeha ka har'a lisele, NAD⁺ e sebetsa e le mochine oa elektronike, o fetisetsa matla ho mitochondria ho khanna tlhahiso ea ATP. ATP e sebetsa e le "mafura" bakeng sa mesebetsi ea cellular, e matlafatsa likarolo tsohle tsa bophelo. Ntle le NAD⁺ e lekaneng, tlhahiso ea matla a cellular ea fokotseha, e lebisang ho fokotseng matla le matla a sebetsang ka kakaretso.
Ka ntle ho metabolism ea matla, NAD⁺ e bapala karolo ea bohlokoa ho lokisoeng ha DNA le botsitso ba genomic. Lisele li lula li pepesehetse tšenyo ea DNA ho tsoa linthong tsa tikoloho le lintho tse hlahisoang ke metabolic, 'me NAD⁺ e kenya tšebetsong li-enzyme tsa ho lokisa ho lokisa liphoso tsena. E boetse e kenya tšebetsong li-sirtuin, lelapa la liprotheine tse amanang le bophelo bo bolelele, ts'ebetso ea mitochondrial, le tekano ea metabolic. Kahoo, NAD⁺ ha e bohlokoa feela bakeng sa ho boloka bophelo bo botle empa hape ke sepheo se seholo lipatlisisong tse khahlanong le botsofali.
NAD⁺ e boetse e bohlokoa ho arabela khatellong ea cellular le ho sireletsa tsamaiso ea methapo. Nakong ea khatello ea oxidative kapa ho ruruha, NAD⁺ e thusa ho laola matšoao a cellular le ho leka-lekana ha ion ho boloka homeostasis. Ts'ebetsong ea methapo, e tšehetsa bophelo bo botle ba mitochondrial, e fokotsa tšenyo ea oxidative ho li-neurone, 'me e thusa ho liehisa ho qala le tsoelo-pele ea mafu a neurodegenerative.
Leha ho le joalo, maemo a NAD⁺ ka tlhaho a theoha ka lilemo. Ho fokotseha hona ho amahanngoa le ho fokotsa tlhahiso ea matla, ho lokisoa ha DNA e sa sebetseng hantle, ho ruruha ho eketsehileng, le ho fokotseha ha tšebetso ea methapo ea kutlo, tseo kaofela e leng matšoao a botsofali le lefu le sa foleng. Ka hona, ho boloka kapa ho phahamisa maemo a NAD⁺ e se e le taba ea mantlha tsamaisong ea sejoale-joale ea bophelo bo botle le lipatlisiso tsa bophelo bo bolelele. Bo-rasaense ba ntse ba hlahloba tlatsetso ka li-precursor tsa NAD⁺ joalo ka NMN kapa NR, hammoho le mehato ea bophelo, ho ts'ehetsa maemo a NAD⁺, ho matlafatsa matla le ho khothaletsa bophelo bo botle ka kakaretso.
Nako ea poso: Aug-20-2025