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Mabitso a felletseng:Motsoako oa Tšireletso ea 'Mele-157,apentadecapeptide (15-amino acid peptide)qalong e ne e arohane le lero la mala a motho.
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Amino acid tatelano:Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, boima ba molek'hule ≈ 1419.55 Da.
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Ha e bapisoa le li-peptide tse ling tse ngata, BPC-157 e batla e tsitsitse metsing le lero la gastric, e leng se etsang hore tsamaiso ea molomo kapa ea gastric e khonehe haholoanyane.
Mekhoa ea Ts'ebetso
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Angiogenesis / Pholiso ea potoloho
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E phahamisaVEGFR-2polelo, ho khothaletsa sebopeho se secha sa methapo ea mali.
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E kenya tshebetsong theTsela ea Src-Caveolin-1-eNOS, e lebisang ho lokolloa ha nitric oxide (NO), vasodilation, le ho ntlafatsa ts'ebetso ea methapo ea mali.
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Anti-inflammatory & Antioxidant
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E theola li-cytokine tsa pro-inflammatory joalo kaIL-6leTNF-α.
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E fokotsa tlhahiso ea oksijene e sebetsang (ROS), e sireletsang lisele ho tsoa khatellong ea oxidative.
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Tokiso ea Maqeba
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E khothaletsa ntlafatso ea sebopeho le ts'ebetso mefuteng ea likotsi tsa tendon, ligament le mesifa.
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E fana ka "neuroprotection" mefuteng ea likotsi tsa tsamaiso ea methapo e bohareng (ho hatella mokokotlo oa mokokotlo, cerebral ischemia-reperfusion), ho fokotsa lefu la neuronal le ho ntlafatsa ho hlaphoheloa ha motlakase / kutlo.
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Taolo ea Mohala oa Vascular
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Lithuto tsa Ex vivo vascular li bonts'a BPC-157 e kenya vasorelaxation, e itšetlehileng ka endothelium e tsitsitseng le NO litsela.
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Liphoofolo & In Vitro Comparative Data
| Mofuta oa Teko | Mohlala / Kenahano | Tekanyetso / Tsamaiso | Taolo | Liphetho tsa Bohlokoa | Lintlha tsa Papiso |
|---|---|---|---|---|---|
| Vasodilation (rat aorta, ex vivo) | Phenylephrine-precontracted aortic mehele | BPC-157 ho fihlela ho100 μg / ml | Ha ho na BPC-157 | Vasorelaxation ~37.6 ± 5.7% | Fokotsoe ho10.0 ± 5.1% / 12.3 ± 2.3%e nang le NOS inhibitor (L-NAME) kapa NO scavenger (Hb) |
| Endothelial cell assay (HUVEC) | HUVEC setso | 1 μg/ml | Taolo e sa alaoeng | ↑ HA HO tlhahiso (makhetlo a 1.35); ↑ ho falla ha lisele | Ho falla ho felisitsoe ka Hb |
| Mohlala oa setho sa Ischemic (rat) | Ischemia ea mokokotlo | 10 μg/kg/letsatsi (ip) | Ha ho kalafo | Pholiso ea phallo ea mali ka potlako, ↑ angiogenesis | Kalafo > Taolo |
| Khatello ea lesapo la mokokotlo (rat) | Khatello ea mokokotlo oa mokokotlo oa Sacrococcygeal | Ente e le 'ngoe ea ip 10 min ka mor'a kotsi | Sehlopha se sa alafshoang | Pholiso ea bohlokoa ea methapo ea kutlo le ea sebopeho | Sehlopha sa taolo se ile sa lula se holofetse |
| Hepatotoxicity mohlala (CCl₄ / joala) | Kotsi ea sebete e bakoang ke lik'hemik'hale | 1 µg kapa 10 ng/kg (ip / ka molomo) | E sa phekoleheng | ↓ AST/ALT, necrosis e fokotsehileng | Sehlopha sa taolo se bontšitse kotsi e matla ea sebete |
| Lithuto tsa chefo | Litoeba, mebutlanyana, lintja | Methati e mengata / litsela | Litaolo tsa placebo | Ha ho chefo e kholo, ha ho LD₅₀ e hlokometsoeng | E mamelloa hantle le ka litekanyetso tse phahameng |
Lithuto tsa Batho
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Letoto la linyeoe: Ente ea intra-articular ea BPC-157 ho bakuli ba 12 ba nang le bohloko ba lengole → 11 e tlalehile bohloko bo boholo ba bohloko. Meeli: ha ho sehlopha sa taolo, ha ho na ho foufala, liphetho tse ikhethileng.
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Teko ea bongaka: Phuputso ea Phase I ea polokeho le pharmacokinetic (NCT02637284) ho baithaopi ba phetseng hantle ba 42 e ile ea etsoa, empa liphetho ha li e-s'o hatisoe.
Hona joale,ha ho na liteko tsa boleng bo holimo tse laoloang ka tšohanyetso (RCTs)li teng ho netefatsa katleho ea tleliniki le polokeho.
Tšireletseho & Likotsi tse ka 'nang tsa etsahala
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Angiogenesis: E molemo bakeng sa pholiso, empa e ka khothaletsa tumor vascularization, ho potlakisa kholo kapa metastasis ho bakuli ba mofetše.
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Lethal dose & Tsamaiso: E sebetsa hantle liphoofolong ka litekanyetso tse tlase haholo (ng–µg/kg), empa tekanyo e nepahetseng ea motho le tsela li lula li sa hlalosoa.
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Tšebeliso ea nako e telele: Ha ho na data e felletseng ea chefo ea nako e telele; lithuto tse ngata ke tsa nakoana.
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Boemo ba taolo: Ha e amoheloe joalo ka sethethefatsi linaheng tse ngata; classified as antho e thibetsoengka WADA (World Anti-Doping Agency).
Maikutlo a Papiso le Meeli
| Papiso | Matla | Mefokolo |
|---|---|---|
| Phoofolo vs Batho | Liphello tse sa fetoheng tse molemo ho liphoofolo (tendon, methapo, tokiso ea sebete, angiogenesis) | Bopaki ba batho bo fokola, ha bo laolehe, 'me ha bo na tatellano ea nako e telele |
| Lethal dose le fapaneng | E sebetsa ka tekanyo e tlase haholo liphoofolong (ng–µg/kg; µg/ml in vitro) | Mokhoa o bolokehileng / o sebetsang oa motho ha o tsejoe |
| Qaleho ya ketso | Tsamaiso ea pele ea kotsi (mohlala, 10 min ka mor'a kotsi ea mokokotlo) e fana ka ho hlaphoheloa ho matla | Bokhoni ba kliniki ba nako e joalo ha bo hlake |
| Chefo | Ha ho tekanyo e bolaeang kapa litlamorao tse mpe tse bonoang mefuteng e mengata ea liphoofolo | Chefo ea nako e telele, carcinogenicity, le polokeho ea pelehi li lula li sa lekoa |
Qetello
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BPC-157 e bonts'a litlamorao tse matla tsa ho nchafatsa le ho sireletsa mefuteng ea liphoofolo le lisele: angiogenesis, anti-inflammation, tokiso ea lisele, neuroprotection, le hepatoprotection.
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Bopaki ba batho bo lekanyelitsoe haholo, ha ho na lintlha tse matla tsa liteko tsa bongaka tse fumanehang.
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Ho feta mooliteko tse laoloang hantle tse hlophisitsoeng hantleli hlokoa ho theha katleho, polokeho, litekanyetso tse nepahetseng, le litsela tsa tsamaiso ho batho.
Nako ea poso: Sep-23-2025