Selelekela
Tirzepatide, e hlahisitsoeng ke Eli Lilly, ke sethethefatsi se secha sa peptide se emelang mohato oa bohlokoa kalafong ea lefu la tsoekere la mofuta oa 2 le botenya. Ho fapana le li-agonists tsa setso tsa GLP-1 (glucagon-like peptide-1), Tirzepatide e sebetsa ka matla.GIP ka bobeli (insulinotropic polypeptide e itšetlehileng ka tsoekere)leLi-receptor tsa GLP-1, ho e fumana lebitso la aagonist ea li-receptor tse peli. Mokhoa ona o habeli o thusa ho laola tsoekere ea mali le ho fokotsa boima ba 'mele, haholo-holo ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le botenya.
Mokhoa oa Ts'ebetso
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Ts'ebetso ea receptor ea GIP: E matlafatsa tlhahiso ea insulin hape e ntlafatsa mamello ea tsoekere.
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Ts'ebetso ea li-receptor tsa GLP-1: E khothalletsa ho lokolloa ha insulin, e hatella secretion ea glucagon, 'me e liehisa ho tsoa ka mpeng.
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Synergy e habeli: E fana ka taolo e sebetsang ea glycemic le phokotso e kholo ea boima ba 'mele.
Tlhahlobo ea Boitsebiso ba Clinical
1. SURPASS Liteko (Mofuta oa 2 oa Lefu la tsoekere)
Ka har'a tse ngataSURPASS liteko tsa meriana, Tirzepatide e ile ea feta insulin le Semaglutide ka liphello tsa glycemic le ho fokotsa boima ba 'mele.
| Sehlopha sa Bakuli | Tekanyetso | Avg. Ho fokotseha ha HbA1c | Avg. Ho Theola boima ba 'mele |
|---|---|---|---|
| Mofuta oa 2 oa lefu la tsoekere | 5 mg | -2.0% | -7.0 lik'hilograma |
| Mofuta oa 2 oa lefu la tsoekere | 10 mg | -2.2% | - 9.5 lik'hilograma |
| Mofuta oa 2 oa lefu la tsoekere | 15 mg | -2.4% | -11.0 lik'hilograma |
➡ Ha e bapisoa le Semaglutide (1 mg: HbA1c -1.9%, Weight -6.0 kg), Tirzepatide e bontšitse liphello tse phahameng ho laola glycemic le ho lahleheloa ke boima ba 'mele.
2. SURMOUNT Liteko (Botenya)
Ho bakuli ba batenya ba se nang lefu la tsoekere, Tirzepatide e bontšitse katleho e makatsang ea ho theola boima ba 'mele.
| Tekanyetso | Avg. Ho fokotsa boima ba 'mele (libeke tse 72) |
|---|---|
| 5 mg | -15% |
| 10 mg | -20% |
| 15 mg | -22.5% |
➡ Bakeng sa mokuli ea boima ba lik'hilograma tse 100, tekanyo e phahameng ea Tirzepatide e ka fokotsa boima ba 'mele ho pota-pota.22,5 lik'hilograma.
Melemo ea Bohlokoa
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Mechini e 'meli: Ka ntle ho li-agonists tse le 'ngoe tsa GLP-1.
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Tšebetso e phahameng: E sebetsa hantle ho taolo ea glycemic le taolo ea boima ba 'mele.
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Bophara bo sebetsang: E loketse lefu la tsoekere le botenya.
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Bokhoni bo phahameng ba 'maraka: Tlhokahalo e ntseng e eketseha ea maemo a kalafo ea botenya Tirzepatide e le sethethefatsi sa blockbuster se tlang.
Pono ea 'Maraka
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Polelo ea boholo ba 'maraka: Ka 2030, 'maraka oa lefats'e oa lithethefatsi oa GLP-1 o lebelletsoe ho fetaUSD 150 limilione tse likete, Tirzepatide e ka 'na ea hapa karolo e ka sehloohong.
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Boemo ba tlholisano: Mohanyetsi ea ka sehloohong ke Semaglutide ea Novo Nordisk (Ozempic, Wegovy).
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Molemo: Lintlha tsa kliniki li bonts'a Tirzepatide e fana ka tahlehelo e phahameng ea boima ba 'mele ha e bapisoa le Semaglutide, e matlafatsang tlhōlisano ea eona ea' maraka kalafo ea botenya.
Nako ea poso: Sep-12-2025