Joalo ka agonist ea GLP-1, e etsisa litlamorao tsa 'mele tsa GLP-1 e lokollotsoeng' meleng.
Karabelo ea ho ja tsoekere, PPG neurons tsamaisong ea methapo e bohareng (CNS) le L-lisele tse ka maleng li hlahisa le ho hlahisa GLP-1, hormone e thibelang mala.
Kamora ho lokolloa, GLP-1 e kenya tšebetsong li-receptor tsa GLP-1R ho pancreatic β-cell, e bakang letoto la liphetoho tsa metabolic tse khetholloang ke secretion ea insulin le khatello ea takatso ea lijo.
Ho haella ha insulin ho lebisa phokotsong ea kakaretso ea tsoekere ea mali, ho fokotseha ha tlhahiso ea glucagon, le ho thibela ho tsoa ha tsoekere ho tsoa mabenkeleng a sebete a glycogen. Sena se etsa hore motho a khore, a ntlafatse kutloisiso ea insulin, 'me qetellong a fokotse boima ba' mele.
Setlhare se hlohlelletsa tlhahiso ea insulin ka mokhoa o itšetlehileng ka tsoekere, ka hona se fokotsa kotsi ea hypoglycemia. Ntle le moo, e na le litlamorao tse ntle tsa nako e telele ho phela, ho ata, le ho nchafatsa lisele tsa β.
Lipatlisiso li bonts'a hore semaglutide e etsisa litlamorao tsa GLP-1 e lokollotsoeng maleng ho fapana le bokong. Lebaka ke hobane li-receptors tse ngata tsa GLP-1 bokong li lutse ka ntle ho mofuta o sebetsang oa litlhare tsena tse tsamaisoang ka mokhoa o hlophisitsoeng. Leha e na le ts'ebetso e lekanyelitsoeng e tobileng ho li-receptor tsa boko ba GLP-1, semaglutide e ntse e sebetsa haholo ho fokotsa ho ja lijo le boima ba 'mele.
Ho bonahala e fihlela sena ka ho kenya tšebetsong marang-rang a neuronal ho pholletsa le tsamaiso ea methapo e bohareng, tseo bongata ba tsona e leng liphofu tsa bobeli tse sa hlahiseng li-receptor tsa GLP-1 ka kotloloho.
Ka 2024, mefuta e amohelehang ea khoebo ea semaglutide e kenyelletsaOzempic, Rybelsus, leWegovyliente, kaofela li entsoe ke Novo Nordisk.
Nako ea poso: Aug-18-2025