Retatrutide e fetola tsela eo botenya bo tšoaroang ka eona

Sechabeng sa kajeno, botenya bo fetohile phephetso ea lefats'e ea bophelo bo botle, le ho hlaha haRetatrutidee fana ka tšepo e ncha bakeng sa bakuli ba loanang le boima bo feteletseng. Retatrutide keagonist ea li-receptor tse tharoho lebelaGLP-1R, GIPR, le GCGR. Mokhoa ona o ikhethang oa synergistic o nang le lipheo tse ngata o bonts'a bokhoni bo sa tloaelehang ba ho theola boima ba 'mele.

Ka mokhoa, Retatrutide e sebetsaLi-receptor tsa GLP-1, e khothalletsang tlhahiso ea insulin, e hatella ho lokolloa ha glucagon, le ho liehisa ho tsoa ka mpeng, kahoo ho matlafatsa ho khora le ho fokotsa ho ja lijo. Ts'ebetso ea eona eaLi-receptor tsa GIPe ntlafatsa kutloisiso ea insulin hape, e laola lipid metabolism, 'me e sebetsa ka tumellano le GLP-1 ho matlafatsa litlamorao tsa ho fokotsa boima ba' mele. Habohlokoa le ho feta, ts'ebetso ea eona eali-glucagon receptors (GCGR)e eketsa tšebeliso ea matla, e ntlafatsa thibelo ea sebete ea gluconeogenesis, 'me e fokotsa ho bokella mafura a sebete-hammoho, litsela tsena li tlatsetsa ho lahleheloa ke boima ba' mele haholo.

Litekong tsa kliniki, liphello tsa tahlehelo ea boima ba Retatrutide e bile tse tsotehang. Thutong ea bongaka ea Mokhahlelo oa 2 ea libeke tse 48, barupeluoa ba fumanang tekanyetso ea beke le beke ea 12 mg ea Retatrutide ba lahlehetsoe ke karolelano ea24.2% ea boima ba 'mele ea bona-sephetho se fetang hōle meriana e mengata ea setso ea ho lahleheloa ke boima ba 'mele le ho atamela katleho ea ho buuoa ka bariatric. Ho feta moo, tahlehelo ea boima ba 'mele e tsoela pele ho ntlafala ha nako e ntse e feta; kabeke ea 72, karolelano ea ho fokotsa boima ba 'mele e fihlile hoo e ka bang28%.

Ka ntle ho phello ea eona e matla ea ho fokotsa boima ba 'mele, Retatrutide e boetse e bontša tšepiso e kholo ea ho ntlafatsa mathata a amanang le botenya. E ka fokotsa khatello ea mali, ea ntlafatsa boemo ba lipids, ea fokotsa maemo a triglyceride, 'me ea fana ka tšireletso ea pelo le methapo ea mali.melemo e felletseng ea bophelo bo botleho batho ba phelang le botenya.