MOTS-c (Mitochondrial Open Reading Frame ea 12S rRNA Type-c) ke peptide e nyane e kentsoeng ke mitochondrial DNA e hohetseng thahasello e kholo ea saense lilemong tsa morao tjena. Ka tloaelo, mitochondria e 'nile ea nkoa e le "matla a matla a sele," a ikarabellang bakeng sa tlhahiso ea matla. Leha ho le joalo, lipatlisiso tse hlahang li senola hore mitochondria e boetse e sebetsa e le lits'ebetso tsa matšoao, tse laolang metabolism le bophelo bo botle ba cellular ka li-peptide tsa bioactive tse kang MOTS-c.
Peptide ena, e nang le li-amino acid tse 16 feela, e kentsoe ka har'a sebaka sa 12S rRNA sa DNA ea mitochondrial. Ha e se e entsoe ka har'a cytoplasm, e ka fetela khubung, moo e susumetsang polelo ea liphatsa tsa lefutso tse amehang taolong ea metabolic. E 'ngoe ea likarolo tsa eona tsa bohlokoa ke ho kenya tšebetsong tsela ea pontšo ea AMPK, e ntlafatsang ho monya le ho sebelisoa ha tsoekere ha e ntse e matlafatsa kutloisiso ea insulin. Lintho tsena li etsa hore MOTS-c e be mokhethoa ea tšepisang bakeng sa ho sebetsana le mathata a metabolic a kang lefu la tsoekere la mofuta oa 2 le botenya.
Ntle le metabolism, MOTS-c e bonts'itse litlamorao tsa ts'ireletso khahlano le khatello ea oxidative ka ho matlafatsa ts'ireletso ea lisele le ho fokotsa tšenyo e bakiloeng ke li-radicals tsa mahala. Mosebetsi ona o thusa ho boloka bophelo bo botle ba litho tsa bohlokoa tse kang pelo, sebete le tsamaiso ea methapo. Lipatlisiso li boetse li totobalitse kamano e hlakileng pakeng tsa maemo a MOTS-c le botsofali: ha 'mele o ntse o hōla, maemo a tlhaho a peptide a fokotseha. Ho tlatselletsa lithutong tsa liphoofolo ho ntlafalitse ts'ebetso ea 'mele, ho lieha ho theoha ho amanang le lilemo, esita le ho lelefatsa nako ea bophelo, ho phahamisa monyetla oa hore MOTS-c e ntlafatsoe e le "molek'hule e thibelang botsofali."
Ho phaella moo, MOTS-c e bonahala e matlafatsa metabolism ea matla a mesifa le mamello, e etsa hore e be thahasello e kholo meriana ea lipapali le ho tsosolosa. Lithuto tse ling li boetse li fana ka maikutlo a melemo e ka bang teng bakeng sa mafu a neurodegenerative, a holisa le ho feta tekano ea kalafo.
Leha e ntse e le methating ea pele ea lipatlisiso, MOTS-c e emetse katleho kutloisisong ea rona ea baeloji ea mitochondrial. Ha e qholotse feela pono e tloaelehileng ea mitochondria empa hape e bula litsela tse ncha tsa ho phekola mafu a metabolism, ho fokotsa botsofali le ho khothalletsa bophelo bo botle ka kakaretso. Ka boithuto bo tsoelang pele le nts'etsopele ea bongaka, MOTS-c e ka fetoha sesebelisoa se matla nakong e tlang ea bongaka.
Nako ea poso: Sep-10-2025