Tirzepatideke agonist e ncha ea li-agonists tsa GIP le GLP-1 receptors, tse lumelletsoeng ho laola glycemic ho batho ba baholo ba nang le lefu la tsoekere la mofuta oa 2 hammoho le taolo ea boima ba nako e telele ho batho ba nang le index ea boima ba 'mele (BMI) ≥30 kg/m², kapa ≥27 kg/m² ba nang le bonyane bo bong bo amanang le boima ba 'mele.
Bakeng sa lefu la tsoekere, e theola tsoekere ea ho itima lijo le ea postprandial ka ho liehisa ho tsoa ka mpeng, ho matlafatsa secretion ea insulin e itšetlehileng ka tsoekere, le ho hatella ho lokolloa ha glucagon, ka kotsi e tlase ea hypoglycemia ha e bapisoa le li-secretagogue tsa insulin tsa setso. Tsamaisong ea botenya, liketso tsa eona tse peli tse bohareng le tsa peripheral li fokotsa takatso ea lijo le ho eketsa tšebeliso ea matla. Liteko tsa meriana li bontšitse hore libeke tse 52-72 tsa phekolo li ka finyella phokotso ea boima ba 'mele ka 15-20%, e tsamaeang le ntlafatso ea sekhahla sa letheka, khatello ea mali le triglycerides.
Liketsahalo tse mpe tse atileng haholo ke matšoao a ka mpeng a bobebe ho isa ho a mahareng, hangata a hlaha libekeng tse 'maloa tsa pele mme a fokotsoa ke ho nyoloha butle ha lethal dose. Ho khothalletsoa ho qala tleliniki tlas'a tlhahlobo ea setsebi sa endocrinologist kapa setsebi sa taolo ea boima ba 'mele, ka tlhahlobo e tsoelang pele ea tsoekere, boima ba' mele le ts'ebetso ea renal. Ka kakaretso, tirzepatide e fana ka khetho ea kalafo e thehiloeng bopaking, e bolokehileng le e tšoarellang bakeng sa bakuli ba hlokang taolo ea glycemic le boima ba 'mele.
Nako ea poso: Aug-27-2025