1. Tlhaloso ea GLP-1
Glucagon-Like Peptide-1 (GLP-1) ke hormone ea tlhaho e hlahang ka maleng ka mor'a ho ja. E bapala karolo ea bohlokoa ho metabolism ea tsoekere ka ho susumetsa tlhahiso ea insulin, ho thibela ho lokolloa ha glucagon, ho liehisa ho tsoa ka mpeng, le ho khothaletsa maikutlo a ho tlala. Liphello tsena tse kopantsoeng li thusa ho laola maemo a tsoekere ea mali le ho kenya letsoho ho laola boima ba 'mele. Synthetic GLP-1 receptor agonists e etsisa lits'ebetso tsena tsa tlhaho, e li etsa tsa bohlokoa kalafong ea lefu la tsoekere la mofuta oa 2 le botenya.
2. Sehlopha ka Mosebetsi
Ho ipapisitsoe le likarolo tsa eona tsa 'mele, GLP-1 le li-analog tsa eona li ka aroloa ka mekhahlelo e mengata ea ts'ebetso:
- Taolo ea tsoekere ea mali: E ntlafatsa ho lokolloa ha insulin ho latela maemo a phahameng a tsoekere ha e ntse e hatella secretion ea glucagon.
- Taolo ea takatso ea lijo: E sebetsa setsing sa boko sa takatso ea lijo ho fokotsa ho ja lijo le ho eketsa ho khora.
- Taolo ea mala: E liehisa ho tsoa ka mpeng, e lelefatsa ts'ebetso ea tšilo ea lijo le ho thusa ho laola ho phahama ha tsoekere ea postprandial.
- Melemo ea pelo: Li-agonists tse ling tsa GLP-1 li bontšitsoe ho fokotsa kotsi ea liketsahalo tse kholo tsa pelo ho bakuli ba nang le lefu la tsoekere.
- Taolo ea boima ba 'mele: Ka ho fokotsa takatso ea lijo le ho khothaletsa phokotso ea lik'halori, li-analog tsa GLP-1 li thusa ho theola boima ba 'mele butle-butle.
3. Litšobotsi tsa GLP-1
GLP-1 e na le halofo ea bophelo ea tlhaho e khutšoane haholo-metsotso e seng mekae feela-hobane e senyeha ka potlako ke enzyme DPP-4 (dipeptidyl peptidase-4). Ho hlola sena, bafuputsi ba tsa meriana ba thehile li-agonists tsa nako e telele tsa maiketsetso tsa GLP-1 joalo ka.Semaglutide, Liraglutide, Tirzepatide, leRetatrutide.
Lik'hemik'hale tsena tse fetotsoeng li eketsa ts'ebetso ho tloha lihora ho ea ho matsatsi kapa esita le libeke, ho lumella ho noa hanngoe ka letsatsi kapa hang ka beke.
Litšobotsi tsa bohlokoa li kenyelletsa:
- Ketso e itšetlehileng ka tsoekere: E fokotsa kotsi ea hypoglycemia ha e bapisoa le kalafo ea insulin ea setso.
- Mekhoa e 'meli kapa e meraro (litlhare tse ncha): Liphetolelo tse ling tse tsoetseng pele li lebisa li-receptor tse eketsehileng tse kang GIP kapa li-glucagon receptors, tse matlafatsang melemo ea metabolism.
- Ntlafatso e pharalletseng ea metabolic: E theola HbA1c, e ntlafatsa boemo ba lipid, hape e thusa ho fokotsa boima ba 'mele.
GLP-1 le li-analogues tsa eona li fetotse phekolo ea sejoale-joale ea metabolic ka ho sebetsana le lefu la tsoekere le botenya ka nako e le 'ngoe - e sa fane feela ka taolo ea tsoekere ea mali empa hape le melemo ea nako e telele ea pelo le boima ba' mele.
4.Litharollo tsa Phekolo ea GLP-1
5. Li-Agonists tse nang le Ente ea GLP-1
Foromo e atileng haholo ea ho fana, tsena li kenyelletsa Liraglutide, Semaglutide, le Tirzepatide. Li tsamaisoa ka tlas'a letlalo, ebang ke letsatsi le letsatsi kapa beke le beke, ho fana ka ts'ebetso e tsoelang pele ea receptor bakeng sa taolo e tsitsitseng ea tsoekere le khatello ea takatso ea lijo.
5. Oral GLP-1 Receptor Agonists
Khetho e ncha, e kang Oral Semaglutide, e fa bakuli boiketlo ba mahala. E sebelisa theknoloji e matlafatsang ho monya ho boloka bioavailability ha e nkuoa ka molomo, ho ntlafatsa ho latela kalafo.
6. Liphekolo Tse Kopanetsoeng (GLP-1 + Litsela Tse Ling)
Liphekolo tse ntseng li hlaha li kopanya GLP-1 le GIP kapa glucagon receptor agonism ho fihlela tahlehelo e matla ea boima ba 'mele le liphetho tsa metabolic. Mohlala, Tirzepatide (e leng agonist e habeli ea GIP/GLP-1) le Retatrutide (GIP/GLP-1/glucagon agonist) e emela moloko o latelang oa kalafo ea metabolism.
Phekolo ea GLP-1 e tšoaea mohato oa phetoho taolong ea mafu a sa foleng a metabolism - e fana ka mokhoa o kopaneng oa ho laola tsoekere ea mali, ho theola boima ba 'mele le ho ntlafatsa liphetho tsa bophelo bo botle ka kakaretso.
Nako ea poso: Nov-03-2025