E kenyelletsa sodium

Tlhaloso e Khutšoanyane:

Inclisiran sodium API (Active Pharmaceutical Ingredient) e ithutoa haholo-holo tšimong ea ho kena-kenana le RNA (RNAi) le therapeutics ea pelo. Joalo ka siRNA e nang le likarolo tse peli e shebileng mofuta oa PCSK9, e sebelisoa lipatlisisong tsa pele le tsa bongaka ho lekola maano a nako e telele a ho khutsisa liphatsa tsa lefutso bakeng sa ho theola LDL-C (low-density lipoprotein cholesterol). E boetse e sebetsa e le motsoako oa mohlala bakeng sa ho batlisisa mekhoa ea phepelo ea siRNA, botsitso, le phekolo ea RNA e lebisitsoeng sebeteng.

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Inclisiran Sodium (API)

Tšebeliso ea Lipatlisiso:
Inclisiran sodium API (Active Pharmaceutical Ingredient) e ithutoa haholo-holo tšimong ea ho kena-kenana le RNA (RNAi) le therapeutics ea pelo. Joalo ka siRNA e nang le likarolo tse peli e shebileng mofuta oa PCSK9, e sebelisoa lipatlisisong tsa pele le tsa bongaka ho lekola maano a nako e telele a ho khutsisa liphatsa tsa lefutso bakeng sa ho theola LDL-C (low-density lipoprotein cholesterol). E boetse e sebetsa e le motsoako oa mohlala bakeng sa ho batlisisa mekhoa ea phepelo ea siRNA, botsitso, le phekolo ea RNA e lebisitsoeng sebeteng.

Mosebetsi:
Inclisiran sodium API e sebetsa ka ho khutsisa mofuta oa PCSK9 ho hepatocyte, e lebisang ho fokotseng tlhahiso ea protheine ea PCSK9. Sena se fella ka ntlafatso e ntlafalitsoeng ea li-receptor tsa LDL le ho hlakoloa ho hoholo ha LDL cholesterol maling. Mosebetsi oa eona e le moemeli oa nako e telele o theolang k'holeseterole o tšehetsa tšebeliso ea oona ho phekola hypercholesterolemia le ho fokotsa kotsi ea lefu la pelo le methapo. Joalo ka API, e theha karolo ea mantlha e sebetsang mekhoeng ea lithethefatsi e thehiloeng ho Inclisiran.

E fetileng: Fmoc-Gly-Gly-OH

E 'ngoe: Donidalorsen

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