Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH

Tšebeliso ea Lipatlisiso:
Fmoc-Thr(tBu)-Phe-OH ke sebaka sa kaho sa dipeptide se atisang ho sebelisoa ho solid-phase peptide synthesis (SPPS). Sehlopha sa Fmoc (9-fluorenylmethyloxycarbonyl) se sireletsa N-terminus, ha sehlopha sa tBu (tert-butyl) se sireletsa ketane ea lehlakore ea hydroxyl ea threonine. Peptide ena e sirelelitsoeng e ithutoa ka karolo ea eona ea ho nolofatsa katoloso e nepahetseng ea peptide, ho fokotsa lebelo la morabe, le ho etsa mohlala oa tatellano e ikhethileng ea sebopeho sa protheine le lithuto tsa tšebelisano.

Mosebetsi:
Fmoc-Thr(tBu) -Phe-OH e sebetsa e le selelekela sa ho kopanya li-peptide tse kenyelletsang masala a threonine le phenylalanine, tse bohlokoa bakeng sa ho theha likamano tsa hydrogen le likamano tsa hydrophobic. Ketane ea lehlakore ea threonine e kenya letsoho polarity le libaka tse ka bang teng tsa phosphorylation, ha phenylalanine e eketsa sebopeho se nkhang hamonate le botsitso ba sebopeho. Motsoako ona o thusa ho rala li-peptide bakeng sa liteko tsa baeloji, lithuto tse tlamang li-receptor, le lits'ebetso tsa ho sibolla lithethefatsi.