"Fitusiran"

Fitusiran (API)

Tšebeliso ea Lipatlisiso:
Fitusiran API ke RNA e nyane e sitisang e nyane (siRNA) e batlisisitsoeng haholo-holo lebaleng la mathata a haemophilia le a coagulation. E lebisitse hoantithrombin (AT kapa SEPINC1)liphatsa tsa lefutso sebeteng ho fokotsa tlhahiso ea antithrombin. Bafuputsi ba sebelisa Fitusiran ho hlahloba mekhoa ea ho kena-kenana le RNA (RNAi), ho khutsisa liphatsa tsa lefutso ka sebete, le mekhoa e mecha ea phekolo ea ho leka-lekanya coagulation ho bakuli ba hemophilia A le B, ba nang le li-inhibitors kapa ba se na tsona.

Mosebetsi:
Fitusiran e sebetsa ka ho khutsisa polelo ea antithrombin, anticoagulant ea tlhaho, ka hona e eketsa tlhahiso ea thrombin le ho khothaletsa ho thehoa ha leqeba. Mokhoa ona o fana ka mokhoa oa kalafo oa prophylactic ho fokotsa liketsahalo tsa mali ho bakuli ba hemophilia. Joaloka API, Fitusiran e sebetsa e le motsoako o sebetsang oa phekolo ea nako e telele ea subcutaneous e reretsoeng ho ntlafatsa boleng ba bophelo le ho fokotsa moroalo oa phekolo mathateng a ho tsoa mali.