Etelcalcetide Hydrochloride

Etelcalcetide Hydrochloride API
Etelcalcetide Hydrochloride ke nova synthetic peptide calcimimetic e ntlafalitsoeng bakeng sa kalafo ea hyperparathyroidism ea bobeli (SHPT) ho bakuli ba nang le lefu la liphio le sa foleng (CKD) ba nang le hemodialysis. SHPT ke bothata bo tloaelehileng le bo tebileng ho bakuli ba CKD, bo khetholloang ke maemo a phahameng a hormone ea parathyroid (PTH), ho sitisa calcium-phosphate metabolism, le kotsi e eketsehileng ea lefu la masapo le pelo.

Etelcalcetide e emela calcimimetic ea moloko oa bobeli, e tsamaisoang ka methapo, 'me e fana ka melemo ho feta liphekolo tsa pele tsa molomo tse kang cinacalcet ka ho ntlafatsa ho lumellana le ho fokotsa litla-morao tsa mala.

Mokhoa oa Ts'ebetso
Etelcalcetide e sebetsa ka ho tlama le ho kenya tšebetsong khalsiamo-sensing receptor (CaSR) e fumanehang liseleng tsa parathyroid. Sena se etsisa phello ea fisioloji ea extracellular calcium, e lebisang ho:

Khatello ea secretion ea PTH

Ho fokotseha ha maemo a serum calcium le phosphate

Ho ntlafala ho leka-lekana ha liminerale le metabolism ea masapo

Joalo ka activator ea allosteric e thehiloeng ho peptide ea CaSR, Etelcalcetide e bonts'a ts'ebetso e ikhethang le ts'ebetso e tsitsitseng kamora tsamaiso ea methapo ea morao-rao ea dialysis.

Lipatlisiso tsa Tleliniki le Phello ea Phekolo
Etelcalcetide e hlahlobiloe haholo litekong tsa kliniki tsa mohato oa 3, ho kenyeletsoa lithuto tsa EVOLVE, AMPLIFY, le EQUIP. Liphuputso tsa bohlokoa li kenyelletsa:

Phokotso e kholo le e tsitsitseng ea maemo a PTH ho bakuli ba CKD ka hemodialysis

Taolo e sebetsang ea serum calcium le phosphorus, e tlatsetsang ntlafatsong ea homeostasis ea masapo-mineral

Mamello e betere ha e bapisoa le calcimimetics ea molomo (ho fokotsoa ho nyekeloa ke pelo le ho hlatsa)

Ho ntlafala ho khomarela bakuli ka lebaka la tsamaiso ea IV ea libeke tse tharo nakong ea li-dialysis

Melemo ena e etsa hore Etelcalcetide e be khetho ea bohlokoa ea phekolo bakeng sa litsebi tsa nephrologists tse laolang SHPT ho dialysis populations.

Boleng le Tlhahiso
Etelcalcetide Hydrochloride API ea rona:

E entsoe ka solid-phase peptide synthesis (SPPS) ka bohloeki bo phahameng

E lumellana le litlhaloso tsa sehlopha sa meriana, tse loketseng ho etsoa ka liente

E bonts'a maemo a tlase a li-solvents tse setseng, litšila le li-endotoxins

E scalable bakeng sa tlhahiso ea li-batch tse kholo tse lumellanang le GMP