NAD+ ke coenzyme ea bohlokoa lits'ebetsong tsa bophelo ba lisele, e bapala karolo ea mantlha ho metabolism ea matla, tokiso ea DNA le anti-botsofali, karabelo ea khatello ea cellular le taolo ea matšoao, hammoho le neuroprotection. Ho metabolism ea matla, NAD+ e sebetsa e le sesebelisoa sa bohlokoa sa elektrone ho glycolysis, tricarboxylic acid cycle, le mitochondrial oxidative phosphorylation, e tsamaisang motsoako oa ATP le ho fana ka matla bakeng sa mesebetsi ea cellular. Ka nako e ts'oanang, NAD + e sebetsa e le karolo ea bohlokoa bakeng sa li-enzyme tsa tokiso ea DNA le activator ea li-sirtuin, ka hona e boloka botsitso ba genomic le ho kenya letsoho bophelong bo bolelele. Tlas'a maemo a khatello ea oxidative le ho ruruha, NAD+ e nka karolo ho bonts'a litsela le taolo ea calcium ho boloka cellular homeostasis. Ts'ebetsong ea methapo, NAD + e ts'ehetsa ts'ebetso ea mitochondrial, e fokotsa tšenyo ea oxidative, 'me e thusa ho liehisa ho qala le tsoelo-pele ea mafu a neurodegenerative. Kaha maemo a NAD+ ka tlhaho a theoha ka lilemo, maano a ho boloka kapa ho ntlafatsa NAD+ a ntse a amoheloa e le a bohlokoa bakeng sa ho khothaletsa bophelo bo botle le ho fokotsa botsofali.